SN-011 | CAS#2249435-90-1 | STING inhibitor

MedKoo Cat#: 556013 | Name: SN-011

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SN-011, also known as GUN35901, is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. GUN35901 is a demethyl analogue of DUN99845 (CAT#556012). GUN35901 was first reported in patent CN 112057443. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

SN-011

CAS#2249435-90-1

Theoretical Analysis

MedKoo Cat#: 556013

Name: SN-011

CAS#: 2249435-90-1

Chemical Formula: C25H19FN2O4S

Exact Mass: 462.1050

Molecular Weight: 462.50

Elemental Analysis: C, 64.92; H, 4.14; F, 4.11; N, 6.06; O, 13.84; S, 6.93

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
25mg	USD 450.00	2 Weeks
50g	USD 750.00	2 Weeks
100mg	USD 1,250.00	2 Weeks
200mg	USD 1,950.00	2 Weeks
500mg	USD 3,250.00	2 Weeks

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Related CAS #

No Data

Synonym

SN-011; SN011; SN 011; GUN35901; GUN-35901; GUN 35901;

IUPAC/Chemical Name

N-(3-((4-fluorophenyl)sulfonamido)-4-hydroxyphenyl)-[1,1'-biphenyl]-4-carboxamide

InChi Key

GPXQUPCJIJBXHJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H19FN2O4S/c26-20-10-13-22(14-11-20)33(31,32)28-23-16-21(12-15-24(23)29)27-25(30)19-8-6-18(7-9-19)17-4-2-1-3-5-17/h1-16,28-29H,(H,27,30)

SMILES Code

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(O)C(NS(=O)(C4=CC=C(F)C=C4)=O)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hong Z, Mei J, Li C, Bai G, Maimaiti M, Hu H, Yu W, Sun L, Zhang L, Cheng D, Liao Y, Li S, You Y, Sun H, Huang J, Liu X, Lieberman J, Wang C. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118. doi: 10.1073/pnas.2105465118. PMID: 34099558; PMCID: PMC8214703. 2: Ni B, Yang Z, Zhou T, Zhou H, Zhou Y, Lin S, Xu H, Lin X, Yi W, He C, Liu X. Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway. J Neuroinflammation. 2024 Jun 25;21(1):164. doi: 10.1186/s12974-024-03155-y. PMID: 38918759; PMCID: PMC11197344. 3: Bi R, Yang Y, Liao H, Ji G, Ma Y, Cai L, Li J, Yang J, Sun M, Liang J, Shi L. Porphyromonas gingivalis induces an inflammatory response via the cGAS- STING signaling pathway in a periodontitis mouse model. Front Microbiol. 2023 Jun 19;14:1183415. doi: 10.3389/fmicb.2023.1183415. PMID: 37405166; PMCID: PMC10315844. 4: Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B. SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses. bioRxiv [Preprint]. 2024 Sep 5:2024.09.05.611469. doi: 10.1101/2024.09.05.611469. PMID: 39282446; PMCID: PMC11398466. 5: Maimaiti M, Li C, Cheng M, Zhong Z, Hu J, Yang L, Zhang L, Hong Z, Song J, Pan M, Ma X, Cui S, Zhang P, Hao H, Wang C, Hu H. Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination. Med. 2024 Jun 14;5(6):622-644.e8. doi: 10.1016/j.medj.2024.03.018. Epub 2024 Apr 24. PMID: 38663402. 6: Yin Z, Li Y, Yu J, Liu Y, Li C, Han X, Shen F. Difference in miRNA expression profiles between two cotton cultivars with distinct salt sensitivity. Mol Biol Rep. 2012 Apr;39(4):4961-70. doi: 10.1007/s11033-011-1292-2. Epub 2011 Dec 8. PMID: 22160515. 7: Tao H, Luo J, Wen Z, Yu G, Su X, Wang X, Guan H, Chen Z. [High STING expression exacerbates renal ischemia-reperfusion injury in mice by regulating the TLR4/NF-κB/NLRP3 pathway and promoting inflammation and apoptosis]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Jul 20;44(7):1345-1354. Chinese. doi: 10.12122/j.issn.1673-4254.2024.07.14. PMID: 39051080; PMCID: PMC11270667.