Related CAS #
730233-46-2 (free base); 40759-33-9 (Br)
Synonym
Nolinium cation; Nolinium Free Base; Diclonium
IUPAC/Chemical Name
2-((3,4-dichlorophenyl)amino)quinolizin-5-ium
InChi Key
MTFYFZDTISVQRR-UHFFFAOYSA-O
InChi Code
InChI=1S/C15H10Cl2N2/c16-14-5-4-11(10-15(14)17)18-12-6-8-19-7-2-1-3-13(19)9-12/h1-10H/p+1
SMILES Code
Clc1c(Cl)cc(Nc(cc2)cc3[n+]2cccc3)cc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
290.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nandi J, Wright MV, Ray TK. Mechanism of gastric antisecretory effects of nolinium bromide. Gastroenterology. 1983 Oct;85(4):938-45. PMID: 6309605.
2: Brooks RR, Jones SM, Moore AF. Effect of nolinium bromide on vascular smooth muscle. Proc Soc Exp Biol Med. 1984 Sep;176(4):452-9. doi: 10.3181/00379727-176-41897. PMID: 6463055.
3: Nandi J, Ray TK. Reaction mechanism of the gastric H+ +K+-dependent ATPase. Effects of inhibitor and pH. Biochem J. 1987 Jan 1;241(1):175-81. doi: 10.1042/bj2410175. PMID: 3032153; PMCID: PMC1147540.
4: Bekker PJ, Gay CV. Biochemical characterization of an electrogenic vacuolar proton pump in purified chicken osteoclast plasma membrane vesicles. J Bone Miner Res. 1990 Jun;5(6):569-79. doi: 10.1002/jbmr.5650050606. PMID: 2166421.
5: Goldenberg MM, Moore RB. Effect of nolinium bromide, cimetidine, and oxyphencyclimine on gastric hypersecretion induced by some secretagogues in the rat. Arch Int Pharmacodyn Ther. 1980 Sep;247(1):163-76. PMID: 7004367.
6: Brooks RR, Goldenberg MM. Inhibition of guinea pig gastric microsomal potassium-stimulated ATPase by nolinium bromide. Proc Soc Exp Biol Med. 1983 Mar;172(3):308-15. doi: 10.3181/00379727-172-41562. PMID: 6302706.
7: Willson RA, Hall T, Hart J. Oxmetidine (H2 receptor antagonist) induced cytotoxicity in isolated rat hepatocytes. J Appl Toxicol. 1988 Jun;8(3):223-5. doi: 10.1002/jat.2550080311. PMID: 2902116.
8: Sasaki T, Tadokoro K, Yanagisawa T, Higashi S, Garant PR. H+-K+-ATPase activity in the rat incisor enamel organ during enamel formation. Anat Rec. 1988 Aug;221(4):823-33. doi: 10.1002/ar.1092210406. PMID: 2847591.
9: Spielmann HP, Wemmer DE, Jacobsen JP. Solution structure of a DNA complex with the fluorescent bis-intercalator TOTO determined by NMR spectroscopy. Biochemistry. 1995 Jul 11;34(27):8542-53. doi: 10.1021/bi00027a004. PMID: 7612596.
10: Dousa TP, Hui YS, Northrup TE, Goldenberg MM. Inhibition of histamine- sensitive adenylate cyclase from the guinea pig gastric mucosa by nolinium bromide. Biochem Pharmacol. 1979;28(2):343-4. doi: 10.1016/0006-2952(79)90528-8. PMID: 426848.
