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MedKoo Cat#: 577030 | Name: MDL-74270

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL-74270 is an N,N,N,-trimethylethanaminium alpha-tocopherol analogue and hydrophilic cardioselective free radical scavenger.

Chemical Structure

MDL-74270
MDL-74270
CAS#128008-97-9

Theoretical Analysis

MedKoo Cat#: 577030

Name: MDL-74270

CAS#: 128008-97-9

Chemical Formula: C27H39NO6S

Exact Mass: 505.2498

Molecular Weight: 505.67

Elemental Analysis: C, 64.13; H, 7.77; N, 2.77; O, 18.98; S, 6.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MDL74270; MDL 74270; MDL-74270
IUPAC/Chemical Name
2-(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)-N,N,N-trimethylethan-1-aminium 4-methylbenzenesulfonate
InChi Key
FUOSWRIOJAAOCD-UHFFFAOYSA-M
InChi Code
InChI=1S/C20H32NO3.C7H8O3S/c1-13-14(2)19-17(15(3)18(13)23-16(4)22)9-10-20(5,24-19)11-12-21(6,7)8;1-6-2-4-7(5-3-6)11(8,9)10/h9-12H2,1-8H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
SMILES Code
CC(=O)Oc1c(C)c(C)c2OC(C)(CC[N+](C)(C)C)CCc2c1C.Cc3ccc(cc3)S(=O)(=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 505.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Petty MA, Dow J, Grisar JM, De Jong W. Effect of a cardioselective alpha-tocopherol analogue on reperfusion injury in rats induced by myocardial ischaemia. Eur J Pharmacol. 1991 Jan 17;192(3):383-8. doi: 10.1016/0014-2999(91)90229-j. PMID: 2055237. 2. Walker MK, Vergely C, Lecour S, Abadie C, Maupoil V, Rochette L. Vitamin E analogues reduce the incidence of ventricular fibrillations and scavenge free radicals. Fundam Clin Pharmacol. 1998;12(2):164-72. doi: 10.1111/j.1472-8206.1998.tb00937.x. PMID: 9565770. 3. Grisar JM, Petty MA, Bolkenius FN, Dow J, Wagner J, Wagner ER, Haegele KD, De Jong W. A cardioselective, hydrophilic N,N,N-trimethylethanaminium alpha-tocopherol analogue that reduces myocardial infarct size. J Med Chem. 1991 Jan;34(1):257-60. doi: 10.1021/jm00105a040. PMID: 1992125. 4. Dow J, Petty MA, Grisar JM, Wagner ER, Haegele KD. Cardioselectivity of alpha-tocopherol analogues, with free radical scavenger activity, in the rat. Drug Metab Dispos. 1991 Nov-Dec;19(6):1040-5. PMID: 1687008. 5. Petty M, Grisar JM, Dow J, De Jong W. Effects of an alpha-tocopherol analogue on myocardial ischaemia and reperfusion injury in rats. Eur J Pharmacol. 1990 Apr 10;179(1-2):241-2. doi: 10.1016/0014-2999(90)90427-8. PMID: 2364988.