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MedKoo Cat#: 464846 | Name: BMS-1016

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-1016 is a Potent PD-L1 Inhibitor with In Vivo Antitumor Activity. BMS-1016 had an EC50 value of 2075 nM.

Chemical Structure

BMS-1016
BMS-1016
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464846

Name: BMS-1016

CAS#: unknown

Chemical Formula: C32H30N2O5

Exact Mass: 522.2155

Molecular Weight: 522.60

Elemental Analysis: C, 73.55; H, 5.79; N, 5.36; O, 15.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BMS-1016; BMS1016; BMS 1016;
IUPAC/Chemical Name
(2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)-D-serine
InChi Key
OUEOAVHGVDLFGR-SSEXGKCCSA-N
InChi Code
InChI=1S/C32H30N2O5/c1-22-27(11-6-12-29(22)25-9-3-2-4-10-25)21-38-28-14-13-26(18-34-30(19-35)32(36)37)31(16-28)39-20-24-8-5-7-23(15-24)17-33/h2-16,30,34-35H,18-21H2,1H3,(H,36,37)/t30-/m1/s1
SMILES Code
CC1=C(COC2=CC=C(CN[C@H](CO)C(O)=O)C(OCC3=CC(C#N)=CC=C3)=C2)C=CC=C1C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 522.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu L, Yao Z, Wang S, Xie T, Wu G, Zhang H, Zhang P, Wu Y, Yuan H, Sun H. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64(12):8391-8409. doi: 10.1021/acs.jmedchem.1c00392. Epub 2021 Jun 11. PMID: 34115499.