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MedKoo Cat#: 414326 | Name: Nepaprazole sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nepaprazole Na is the salt form of Nepaprazole Free Base, also known as TY-11345, is a proton pump inhibitor potentially for treatment of gastric ulcer. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes; and the inhibitory effect was enhanced under weak acid conditions, the IC50 (concentrations that inhibit the enzyme activity by 50%) being 5.8 microM and 9.9 microM at pH 6.0 and pH 7.4, respectively. TY-11345 should be useful for the clinical treatment of peptic ulcer diseases.

Chemical Structure

Nepaprazole sodium
Nepaprazole sodium
CAS#157564-11-9 (Na)

Theoretical Analysis

MedKoo Cat#: 414326

Name: Nepaprazole sodium

CAS#: 157564-11-9 (Na)

Chemical Formula: C18H18N3NaO2S

Exact Mass: 363.1017

Molecular Weight: 363.41

Elemental Analysis: C, 59.49; H, 4.99; N, 11.56; Na, 6.33; O, 8.80; S, 8.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
157564-11-9 (Na) 156601-79-5 (free base)
Synonym
Nepaprazole Na; Nepaprazole sodium; Penaprazole sodium
IUPAC/Chemical Name
5h-cyclohepta(b)pyridine, 9-((r)-1h-benzimidazol-2-ylsulfinyl)-6,7,8,9-tetrahydro-4-methoxy-, sodium salt (1:1), (9s)-rel
InChi Key
LDRXBZROLSTTFO-ROMIFTKDSA-N
InChi Code
InChI=1S/C18H18N3O2S.Na/c1-23-15-10-11-19-17-12(15)6-2-5-9-16(17)24(22)18-20-13-7-3-4-8-14(13)21-18;/h3-4,7-8,10-11,16H,2,5-6,9H2,1H3;/q-1;+1/t16-,24?;/m0./s1
SMILES Code
COC1=C(CCCC[C@@H]2S(C3=NC4=CC=CC=C4[N-]3)=O)C2=NC=C1.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamada S, Goto T, Yuasa S, Yamaguchi T, Kogi K. [Synthesis of stable solvates of monosodium 2-[R*s,9S*)-(4-methoxy-6,7,8, 9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole]. Yakugaku Zasshi. 1996 Aug;116(8):657-70. Japanese. PubMed PMID: 8831267. 2: Yamada S, Goto T, Yamaguchi T, Aihara K, Kogi K, Narita S. Synthetic study of 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9- yl)-sulfinyl]-1H-benzimidazole analogs and their biological properties as novel proton pump inhibitors. Chem Pharm Bull (Tokyo). 1995 Mar;43(3):421-31. PubMed PMID: 7774025. 3: Uematsu T, Nakano M, Kosuge K, Nagai A, Sato A, Nakashima M. Pharmacokinetic properties of a novel gastric proton pump inhibitor, (+/-)-2-[(4-methoxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9- yl)sulfinyl]-1H-benzimidazole sodium salt, in healthy subjects. J Pharm Sci. 1994 Oct;83(10):1407-11. PubMed PMID: 7884660. 4: Yamada S, Goto T, Shimanuki E, Narita S. Synthesis and antiulcer activities of novel 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H- benzimidazole analogues. Chem Pharm Bull (Tokyo). 1994 Mar;42(3):718-20. PubMed PMID: 8004722. 5: Yamaguchi T, Aihara K, Yamada S, Narita S, Kogi K. Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals. Jpn J Pharmacol. 1993 Aug;62(4):363-71. PubMed PMID: 8230863.