Synonym
Thonzylamine Free Base; BRN0284655; BRN-0284655; BRN 0284655; NCIC60708; NCI C60708; NCI-C60708
IUPAC/Chemical Name
1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyrimidinyl-
InChi Key
GULNIHOSWFYMRN-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3
SMILES Code
CN(C)CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
286.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sabry SM, Abdel-Hay MH, Barary MH, Belal TS. Sensitive spectrofluorimetric and spectrophotometric methods for the determination of thonzylamine hydrochloride in pharmaceutical preparations based on coupling with dimethylbarbituric acid in presence of dicyclohexylcarbodiimide. J Pharm Biomed Anal. 2000 Mar;22(2):257-64. doi: 10.1016/s0731-7085(99)00261-7. PMID: 10719908.
2: Zhou S, Huang G, Chen G. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15;27(24):115127. doi: 10.1016/j.bmc.2019.115127. Epub 2019 Nov 1. PMID: 31703894.
3: DUCA CJ, ROTHLAUF MV, SCUDI JV. Further studies on thonzylamine in treatment of experimental tuberculosis. Proc Soc Exp Biol Med. 1951 Aug;77(4):641-3. doi: 10.3181/00379727-77-18876. PMID: 14891823.
4: DREYER NB, SLAVIN WJ. Effect of an antihistaminic drug (thonzylamine) on uterine contractility. J Am Med Womens Assoc. 1954 Feb;9(2):35-8. PMID: 13142908.
5: ARMINIO JJ, SWEET CC. The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride). Ind Med Surg. 1949 Dec;18(12):509-11. PMID: 15393969.
6: GRAHAM JD. Substituted ethylenediamines related to thonzylamine. Arch Int Pharmacodyn Ther. 1960 Jan 1;123:419-29. PMID: 13828806.
7: LANDIS C, ZUBIN J. The alleged sedative effect of thonzylamine hydrochloride (neoheteramine). J Lab Clin Med. 1951 Dec;38(6):873-80. PMID: 14889075.
8: Mossini F, Maggiali C, Morini G, Impicciatore M, Morini G, Molina E. Composti 4-[benzil-(2-dimetilaminoetil)amino]-pirimidinici antagonisti selettivi dei recettori H1-istaminici [4-[Benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds with selective antagonistic activity against H1-histamine receptors]. Farmaco Sci. 1984 Mar;39(3):189-99. Italian. PMID: 6143687.
9: REINHARD JF, SCUDI JV. Daily administration of massive oral doses of thonzylamine hydro-chloride. Proc Soc Exp Biol Med. 1950 May;74(1):190-1. PMID: 15430430.
10: Nakano S, Taniguchi H, Furuhashi T. [Fluorometric analysis with o-aminothiophenol. II. Fluorometric determination of thonzylamine hydrochloride]. Yakugaku Zasshi. 1972 Apr;92(4):411-6. Japanese. doi: 10.1248/yakushi1947.92.4_411. PMID: 5065436.
