Synonym
Neltenexine HCl; Neltenexine hydrochloride
IUPAC/Chemical Name
N-(2,4-dibromo-6-((((1r,4r)-4-hydroxycyclohexyl)amino)methyl)phenyl)thiophene-2-carboxamide hydrochloride
InChi Key
ZVPWQPVEYLBIFG-SKKCDYJJSA-N
InChi Code
InChI=1S/C18H20Br2N2O2S.ClH/c19-12-8-11(10-21-13-3-5-14(23)6-4-13)17(15(20)9-12)22-18(24)16-2-1-7-25-16;/h1-2,7-9,13-14,21,23H,3-6,10H2,(H,22,24);1H/t13-,14-;
SMILES Code
O[C@@H]1CC[C@@H](NCc2c(NC(c3sccc3)=O)c(Br)cc(Br)c2)CC1.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
524.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y. Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun. 2007 May 18;356(4):1050-5. Epub 2007 Mar 26. PubMed PMID: 17400191.
2: Cattaneo C. Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo. Minerva Med. 2001 Aug;92(4):277-84. PubMed PMID: 11535971.
3: Fadda G. Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol. Minerva Med. 2001 Aug;92(4):269-75. PubMed PMID: 11535970.
4: Braga PC, Piatti G, Limoli A, Dal Sasso M, Maci S. Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Drugs Exp Clin Res. 1995;21(2):51-7. PubMed PMID: 7555609.
5: Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev. 2014 Mar 10;(3):CD006088. doi: 10.1002/14651858.CD006088.pub4. Review. PubMed PMID: 24615334.
6: Molassiotis A, Bryan G, Caress A, Bailey C, Smith J. Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: A systematic review of the literature. Respir Med. 2010 Jul;104(7):934-44. doi: 10.1016/j.rmed.2010.02.010. Epub 2010 Apr 10. Review. PubMed PMID: 20385478.
7: Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD006088. doi: 10.1002/14651858.CD006088.pub3. Review. Update in: Cochrane Database Syst Rev. 2014;(3):CD006088. PubMed PMID: 22336815.
8: Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006088. Review. Update in: Cochrane Database Syst Rev. 2012;2:CD006088. PubMed PMID: 17943884.
