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MedKoo Cat#: 208085 | Name: GRL-8234

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GRL-8234 is a small-molecule BACE1 inhibitor that reverses memory impairments and age-related cognitive decline.

Chemical Structure

GRL-8234
GRL-8234
CAS#913071-81-5

Theoretical Analysis

MedKoo Cat#: 208085

Name: GRL-8234

CAS#: 913071-81-5

Chemical Formula: C36H42N4O6S

Exact Mass: 658.2825

Molecular Weight: 658.81

Elemental Analysis: C, 65.63; H, 6.43; N, 8.50; O, 14.57; S, 4.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GRL 8234; GRL-8234; GRL8234
IUPAC/Chemical Name
N1-((2S,3R)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2-yl)-5-(N-methylmethylsulfonamido)-N3-((R)-1-phenylethyl)isophthalamide
InChi Key
HIQWWDCRULXYDF-SWROZOJRSA-N
InChi Code
InChI=1S/C36H42N4O6S/c1-25(28-15-9-6-10-16-28)38-35(42)29-20-30(22-31(21-29)40(2)47(4,44)45)36(43)39-33(19-26-12-7-5-8-13-26)34(41)24-37-23-27-14-11-17-32(18-27)46-3/h5-18,20-22,25,33-34,37,41H,19,23-24H2,1-4H3,(H,38,42)(H,39,43)/t25-,33+,34-/m1/s1
SMILES Code
COC1=CC(CNC[C@@H](O)[C@@H](NC(C2=CC(C(N[C@H](C)C3=CC=CC=C3)=O)=CC(N(S(=O)(C)=O)C)=C2)=O)CC4=CC=CC=C4)=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 658.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Ohno M. Accelerated long-term forgetting is a BACE1 inhibitor-reversible incipient cognitive phenotype in Alzheimer's disease model mice. Neuropsychopharmacol Rep. 2021 Jun;41(2):255-259. doi: 10.1002/npr2.12174. Epub 2021 Mar 22. PMID: 33749160; PMCID: PMC8340838. 2. Devi L, Tang J, Ohno M. Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression. Curr Alzheimer Res. 2015;12(1):13-21. doi: 10.2174/1567205012666141218125042. PMID: 25523425; PMCID: PMC4414026. 3. Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J. 2011 Feb;25(2):775-84. doi: 10.1096/fj.10-167213. Epub 2010 Nov 8. PMID: 21059748; PMCID: PMC3023390.

View History

MDL-29913

MDL-29913