CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). The family of Polo-like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and selective inhibitors of PLK4.
MedKoo Cat#: 408157
Name: CFI-400437 HCl
CAS#: 1247000-76-5 (HCl)
Chemical Formula: C29H30Cl2N6O2
Exact Mass: 0.0000
Molecular Weight: 565.50
Elemental Analysis: C, 61.59; H, 5.35; Cl, 12.54; N, 14.86; O, 5.66
The following data is based on the product molecular weight 565.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
