Synonym
Fazadinium Free Base; Dazopironium
IUPAC/Chemical Name
Imidazo(1,2-a)pyridinium, 1,1'-azobis(3-methyl-2-phenyl-
InChi Key
NJAGGYXZTILBMJ-QVIHXGFCSA-N
InChi Code
InChI=1S/C28H24N6/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31(21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24/h3-20H,1-2H3/q+2/b30-29+
SMILES Code
Cc1c(c2ccccc2)n(\N=N\n3c(c(C)[n+]4ccccc34)c5ccccc5)c6cccc[n+]16
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
444.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Esener Z. The use of fazadinium in children. An electromyographic study. Br J Anaesth. 1983 Dec;55(12):1205-12. doi: 10.1093/bja/55.12.1205. PMID: 6140023.
2: Hartley JM, Fidler K. Rapid intubation with fazadinium. A comparison of fazadinium with suxamethonium and alcuronium. Anaesthesia. 1977 Jan;32(1):14-20. doi: 10.1111/j.1365-2044.1977.tb11551.x. PMID: 15467.
3: Bevan DR, D'Souza J, Rouse JM, Caldwell J, Smith RL. Clinical pharmacokinetics of fazadinium. Anaesthesia. 1980 Sep;35(9):873-8. doi: 10.1111/j.1365-2044.1980.tb03946.x. PMID: 6108730.
4: d'Hollander AA, Duvaldestin P, Delcroix C, Nevelsteen M, Desmonts JM. Evolution of single twitch and train-of-four responses and of tetanic fade in relation to plasma concentrations of fazadinium in man. Anesth Analg. 1982 Mar;61(3):225-30. PMID: 6121521.
5: Blackburn CL, Morgan M. Comparison of speed of onset of fazadinium, pancuronium, tubocurarine and suxamethonium. Br J Anaesth. 1978 Apr;50(4):361-4. doi: 10.1093/bja/50.4.361. PMID: 26369.
6: Hughes R, Payne JP, Sugai N. Studies on fazadinium bromide (ah 8165): a new non-depolarizing neuromuscular blocking agent. Can Anaesth Soc J. 1976 Jan;23(1):36-47. doi: 10.1007/BF03004993. PMID: 2378.
7: Kienlen J, du Callar J. Pharmacologie du fazadinium (AH 8165) [Pharmacology of fazadinium (AH 8165)]. Ann Anesthesiol Fr. 1981;22(6):631-9. French. PMID: 6124193.
8: Rainaldi MP, Busi T, Melloni C, Boschi S. Pharmacokinetics and placental transmission of fazadinium in elective caesarean sections. Acta Anaesthesiol Scand. 1984 Apr;28(2):222-5. doi: 10.1111/j.1399-6576.1984.tb02047.x. PMID: 6145279.
9: Hull CJ, English MJ, Sibbald A. Fazadinium and pancuronium: a pharmacodynamic study. Br J Anaesth. 1980 Dec;52(12):1209-21. doi: 10.1093/bja/52.12.1209. PMID: 6108777.
10: d'Hollander AA, Duvaldestin P, Henzel D, Delcroix C, Desmonts JM. Relationship between decay of plasma concentration of fazadinium and recovery from its neuromuscular blocking effect. Br J Anaesth. 1981 Aug;53(8):853-8. doi: 10.1093/bja/53.8.853. PMID: 6115662.
