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MedKoo Cat#: 591424 | Name: Fazadinium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fazadinium bromide is a muscle relaxant which acts as a nicotinic acetylcholine receptor antagonist through neuromuscular blockade.

Chemical Structure

Fazadinium bromide
Fazadinium bromide
CAS#49564-56-9 (Br)

Theoretical Analysis

MedKoo Cat#: 591424

Name: Fazadinium bromide

CAS#: 49564-56-9 (Br)

Chemical Formula: C28H24Br2N6

Exact Mass: 602.0429

Molecular Weight: 604.35

Elemental Analysis: C, 55.65; H, 4.00; Br, 26.44; N, 13.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
36653-54-0 (free base) 49564-56-9 (Br)
Synonym
Fazadinium bromide;
IUPAC/Chemical Name
1H-Imidazo(1,2-a)pyridin-4-ium, 1,1'-azobis(3-methyl-2-phenyl-, dibromide
InChi Key
LBOZSXSPRGACHC-NFOZGECASA-L
InChi Code
InChI=1S/C28H24N6.2BrH/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31(21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24;;/h3-20H,1-2H3;2*1H/q+2;;/p-2/b30-29+;;
SMILES Code
CC1=C(C2=CC=CC=C2)N(/N=N/N3C(C4=CC=CC=C4)=C(C)[N+]5=CC=CC=C53)C6=CC=CC=[N+]61.[Br-].[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 604.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Esener Z. A clinical study on vecuronium in children: a comparison with fazadinium and pancuronium. Turk J Pediatr. 1988 Jul-Sep;30(3):163-72. PubMed PMID: 2907392. 2: Alvarez Gómez JA, Brugger AJ, Pérez Guillermo F, Lozano Tonkin E, Martínez Pretel C, Gil Sánchez JC. [Electromyographic study of the effects of vecuronium bromide compared with those of pancuronium, tubocurarine, fazadinium and suxamethonium]. Rev Esp Anestesiol Reanim. 1987 Jul-Aug;34(4):237-46. Spanish. PubMed PMID: 2889244. 3: Baurain M, Dernovoi B, Lefebvre R, Barvais L, d'Hollander A, Duvaldestin P, Hennart D. [Spontaneous development of paralysis induced by equipotent doses of vecuronium, atracurium, fazadinium, pancuronium, gallamine and d-tubocurarine]. Ann Fr Anesth Reanim. 1987;6(6):493-7. French. PubMed PMID: 2894787. 4: Harle DG, Baldo BA, Fisher MM. Cross-reactivity of metocurine, atracurium, vecuronium and fazadinium with IgE antibodies from patients unexposed to these drugs but allergic to other myoneural blocking drugs. Br J Anaesth. 1985 Nov;57(11):1073-6. PubMed PMID: 2864946. 5: Stella L, Falivene R, Gargiulo G, Mastronardi P, Cafiero T, De Santis L. [Changes in intracranial pressure during muscle relaxation with fazadinium bromide]. Minerva Anestesiol. 1984 Apr;50(4):123-5. Italian. PubMed PMID: 6147795. 6: Busi T, Rainaldi MP, Melloni C, Boschi S, Pirazzoli A. [Fazadinium bromide. Preliminary note on its clinical pharmacokinetics]. Minerva Anestesiol. 1983 Sep;49(9):485-9. Italian. PubMed PMID: 6140666. 7: Lusini A, Pappagallo S, Ferri L, Di Grancio R, Del Dotto P. [Personal experience with the use of fazadinium bromide in eye surgery]. Minerva Anestesiol. 1983 Jun;49(6):393-8. Italian. PubMed PMID: 6137793. 8: Falcone G, Scarponi L. [The use of fazadinium bromide, a new synthetic muscle relaxant, in general surgery]. Minerva Anestesiol. 1983 Jun;49(6):381-3. Italian. PubMed PMID: 6137791. 9: Minutella G, Bongiovanni G. [The use of fazadinium bromide, a non-depolarizing muscle relaxant, in tracheal intubation]. Minerva Anestesiol. 1983 May;49(5):301-3. Italian. PubMed PMID: 6136939. 10: d'Hollander AA, Delcroix C, Duvaldestin P, Henzel D, Coussaert E, Desmonts JM. Analytical model of some pharmacokinetic and pharmacodynamic properties of fazadinium in man. Eur J Clin Pharmacol. 1983;24(3):407-13. PubMed PMID: 6134623. 11: Duvaldestin P, Henzel D. Binding of tubocurarine, fazadinium, pancuronium and Org NC 45 to serum proteins in normal man and in patients with cirrhosis. Br J Anaesth. 1982 May;54(5):513-6. PubMed PMID: 6122460. 12: Nanni Costa P, Gordini G, Gregorini P, Marchi S, Trombetti P. [First experience with fazadinium bromide in a general surgery department]. Minerva Anestesiol. 1982 Mar;48(3):137-44. Italian. PubMed PMID: 6124905. 13: Dagnino A, Nurra V, Nurra P. [Experience in the use of fazadinium bromide in anesthesia]. Minerva Anestesiol. 1982 Mar;48(3):133-6. Italian. PubMed PMID: 6124904. 14: Beltrutti D, Pellegrino R, Alessandrini A, Cussino R. [A new non-depolarizing muscle relaxant. Initial clinical experiences with fazadinium bromide]. Minerva Anestesiol. 1982 Mar;48(3):121-5. Italian. PubMed PMID: 6124902. 15: Zaffiri O, Marchetti G, Perani R, Giuntelli V, Verdecchia C, Schifone G, Belloni GP. [First clinical experiences with a new fast-acting, non-depolarizing muscle relaxant, fazadinium bromide]. Minerva Anestesiol. 1982 Mar;48(3):105-12. Italian. PubMed PMID: 6124900. 16: Famewo CE, Elegbe EO. Post-suxamethonium pains in Nigerian surgical patients. Middle East J Anaesthesiol. 1982 Feb;6(4):215-8. PubMed PMID: 7176945. 17: Macoretta P, Poletto TA, Paciello F. [Influence of serum proteins on the action of fazadinium bromide]. Ann Osp Maria Vittoria Torino. 1982 Jan-Jun;25(1-6):46-53. Italian. PubMed PMID: 6136251. 18: Famewo CE. Clinical trial of fazadinium bromide (fazadon). Can Anaesth Soc J. 1981 Mar;28(2):149-52. PubMed PMID: 6113885. 19: Famewo CE, Fajimi JL. Changes in plasma potassium and sodium following fazadinium bromide. Anaesthesia. 1981 Feb;36(2):226-7. PubMed PMID: 6111263. 20: Bevan DR, D'Souza JD, Rouse JM, Caldwell J, Smith RL. Clinical pharmacokinetics and pharmacodynamics of fazadinium in renal failure. Eur J Clin Pharmacol. 1981;20(4):293-8. PubMed PMID: 6118278.

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