MedKoo Cat#: 414153 | Name: Eucaine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eucaine Free Base is a drug that was previously used as a local anesthetic. It was designed as an analog of cocaine and was one of the first synthetic chemical compounds to find general use as an anesthetic. It is a white, crystalline solid.

Chemical Structure

Eucaine Free Base
Eucaine Free Base
CAS#500-34-5 (free base)

Theoretical Analysis

MedKoo Cat#: 414153

Name: Eucaine Free Base

CAS#: 500-34-5 (free base)

Chemical Formula: C15H21NO2

Exact Mass: 247.1572

Molecular Weight: 247.34

Elemental Analysis: C, 72.84; H, 8.56; N, 5.66; O, 12.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Eucaine Free Base; NSC49860; NSC-49860; NSC 49860
IUPAC/Chemical Name
4-Piperidinol, 2,2,6-trimethyl-, benzoate (ester)
InChi Key
ZYHGIAPHLSTGMX-WCQYABFASA-N
InChi Code
InChI=1S/C15H21NO2/c1-11-9-13(10-15(2,3)16-11)18-14(17)12-7-5-4-6-8-12/h4-8,11,13,16H,9-10H2,1-3H3/t11-,13+/m0/s1
SMILES Code
C[C@H]1C[C@@H](OC(c2ccccc2)=O)CC(C)(N1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 247.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Eucaine Lactate. Hospital (Lond 1886). 1904 Oct 15;37(942):47. PMID: 29817996; PMCID: PMC5208468. 2: Ruetsch YA, Böni T, Borgeat A. From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem. 2001 Aug;1(3):175-82. doi: 10.2174/1568026013395335. PMID: 11895133. 3: Copeland AJ. Beta-Eucaine Borate. Br Med J. 1926 Jan 16;1(3394):82-3. doi: 10.1136/bmj.1.3394.82. PMID: 20772315; PMCID: PMC2522591. 4: Eucaine Lactate. Hospital (Lond 1886). 1905 May 27;38(974):153. PMID: 29811155; PMCID: PMC5188183. 5: Eucaine Anæsthesia. Hospital (Lond 1886). 1900 Apr 7;28(706):13. PMID: 29839321; PMCID: PMC5272308. 6: Bause GS. Beta-eucaine bottle. Anesthesiology. 2009 Feb;110(2):386. doi: 10.1097/01.anes.0000345311.85812.d3. PMID: 19164961. 7: Coyte R. The Clinical Use of Borocaine Borate and Beta-Eucaine Borate for Urethral Anaesthesia. Br Med J. 1926 Jan 16;1(3394):84-5. doi: 10.1136/bmj.1.3394.84. PMID: 20772317; PMCID: PMC2522623. 8: Horne WJ, Yearsley M. Eucaine as a Local Anaesthetic in the Surgery of the Throat, Nose, and Ear: [Preliminary Communication.]. Br Med J. 1897 Jan 16;1(1881):134-6. doi: 10.1136/bmj.1.1881.134. PMID: 20756737; PMCID: PMC2432770. 9: Perks F, Russell PJ. The configuration of beta-eucaine and beta-isoeucaine. J Pharm Pharmacol. 1967 May;19(5):318-21. doi: 10.1111/j.2042-7158.1967.tb08093.x. PMID: 4382404. 10: Davis GG. IV. Laryngectomy under Eucaine Anaesthesia, with Remarks on the Technique of the Operation. Ann Surg. 1901 Jan;33(1):32-8. doi: 10.1097/00000658-190101000-00004. PMID: 17860921; PMCID: PMC1425191.