YM-31636 | CAS#159081-22-8 | 5-HT3 receptor agonist

MedKoo Cat#: 145288 | Name: YM-31636

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YM-31636 is a 5-HT3 receptor agonist. YM-31636 induced contraction of isolated guinea pig distal colon. YM-31636 is a potent and selective 5-HT3 receptor agonist, preferentially acting on the contraction of the colon. YM-31636 is shown to increase the intracolonic pressure measured in both conscious and anesthetized rats. YM-31636 may be useful in treating constipation since they facilitate GMC-like contractions and defecation without undesired changes in gut motility pattern.

Chemical Structure

YM-31636

CAS#159081-22-8

Theoretical Analysis

MedKoo Cat#: 145288

Name: YM-31636

CAS#: 159081-22-8

Chemical Formula: C14H11N3S

Exact Mass: 253.0674

Molecular Weight: 253.32

Elemental Analysis: C, 66.38; H, 4.38; N, 16.59; S, 12.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

YM-31636; YM31636; YM 31636;

IUPAC/Chemical Name

2-((1H-imidazol-4-yl)methyl)-8H-indeno[1,2-d]thiazole

InChi Key

SWXJBBYBDXFMGG-UHFFFAOYSA-N

InChi Code

1S/C14H11N3S/c1-2-4-11-9(3-1)5-12-14(11)17-13(18-12)6-10-7-15-8-16-10/h1-4,7-8H,5-6H2,(H,15,16)

SMILES Code

C(C1=CNC=N1)C2=NC3=C(CC4=C3C=CC=C4)S2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 253.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ito H, Kiso T, Miyata K, Kamato T, Yuki H, Akuzawa S, Nagakura Y, Yamano M, Suzuki M, Naitoh Y, Sakai H, Iwaoka K, Yamaguchi T. Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409(2):195-201. doi: 10.1016/s0014-2999(00)00851-7. PMID: 11104834. 2: Kiso T, Ito H, Miyata K, Kamato T, Naitoh Y, Iwaoka K, Yamaguchi T. A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain. Eur J Pharmacol. 2001 Nov 9;431(1):35-41. doi: 10.1016/s0014-2999(01)01425-x. PMID: 11716840. 3: Ito H, Kiso T, Yuki H, Naitoh Y, Miyata K, Iwaoka K, Yamaguchi T. Investigation of the effects of YM-31636, a novel 5-HT3 receptor agonist, on defecation in normal and constipated ferrets. Eur J Pharmacol. 2001 Jul 20;424(2):151-7. doi: 10.1016/s0014-2999(01)01147-5. PMID: 11476761. 4: Hang LH, Shao DH, Wang H, Yang JP. Involvement of 5-hydroxytryptamine type 3 receptors in sevoflurane-induced hypnotic and analgesic effects in mice. Pharmacol Rep. 2010 Jul-Aug;62(4):621-6. doi: 10.1016/s1734-1140(10)70319-4. PMID: 20885002. 5: Nagakura Y, Kiso T, Miyata K, Ito H, Iwaoka K, Yamaguchi T. The effect of the selective 5-HT(3) receptor agonist on ferret gut motility. Life Sci. 2002 Aug 2;71(11):1313-9. doi: 10.1016/s0024-3205(02)01841-6. PMID: 12106596. 6: Imanishi N, Iwaoka K, Koshio H, Nagashima SY, Kazuta K, Ohta M, Sakamoto S, Ito H, Akuzawa S, Kiso T, Tsukamoto S, Mase T. New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation. Bioorg Med Chem. 2003 Apr 3;11(7):1493-502. doi: 10.1016/s0968-0896(02)00557-6. PMID: 12628674.