MedKoo Cat#: 555997 | Name: CDC 5-LO inhibitor
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent and direct inhibitor of 5-LO (5-Lipoxygenase) that reduces 5-LO activity in cell-free assays. CDC also inhibits 12-LO and 15-LO

Chemical Structure

CDC 5-LO inhibitor
CDC 5-LO inhibitor
CAS#132465-11-3

Theoretical Analysis

MedKoo Cat#: 555997

Name: CDC 5-LO inhibitor

CAS#: 132465-11-3

Chemical Formula: C19H15NO4

Exact Mass: 321.1001

Molecular Weight: 321.33

Elemental Analysis: C, 71.02; H, 4.71; N, 4.36; O, 19.92

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,250.00 2 Weeks
1g USD 1,950.00 2 Weeks
2g USD 3,450.00 2 Weeks
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Related CAS #
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Synonym
CDC 5-LO inhibitor; Cinnamyl-3,4-dihydroxy-α-cyanocinnamate;
IUPAC/Chemical Name
3-Phenyl-2-propen-1-yl (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate
InChi Key
XGHYFEJMJXGPGN-UYHGDYIZSA-N
InChi Code
InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+
SMILES Code
O=C(OC/C=C/C1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 321.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Wang X, Gao L, Xiao L, Yang L, Li W, Liu G, Chen L, Zhang J. 12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury. J Diabetes Investig. 2019 May;10(3):639-649. doi: 10.1111/jdi.12941. Epub 2018 Oct 24. PMID: 30251333; PMCID: PMC6497583.