MedKoo Cat#: 584975 | Name: Tetrofosmin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.

Chemical Structure

Tetrofosmin
CAS#127502-06-1

Theoretical Analysis

MedKoo Cat#: 584975

Name: Tetrofosmin

CAS#: 127502-06-1

Chemical Formula: C18H40O4P2

Exact Mass: 382.2402

Molecular Weight: 382.46

Elemental Analysis: C, 56.53; H, 10.54; O, 16.73; P, 16.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tetrofosmin; P 53; P53
IUPAC/Chemical Name
3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-
InChi Key
QCWJONLQSHEGEJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H40O4P2/c1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4/h5-18H2,1-4H3
SMILES Code
CCOCCP(CCOCC)CCP(CCOCC)CCOCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Feasibility and diagnostic accuracy of a gated SPECT early-imaging protocol: a multicenter study of the Myoview Imaging Optimization Group. J Nucl Med. 2007 Oct;48(10):1670-5. Epub 2007 Sep 14. PubMed PMID: 17873126. 4: Glover DK, Ruiz M, Yang JY, Smith WH, Watson DD, Beller GA. Myocardial 99mTc-tetrofosmin uptake during adenosine-induced vasodilatation with either a critical or mild coronary stenosis: comparison with 201Tl and regional myocardial blood flow. Circulation. 1997 Oct 7;96(7):2332-8. PubMed PMID: 9337208. 5: Torreggiani W, Brenner C, Hogan B. Incidental diagnosis of breast carcinoma following technetium 99m tetrofosmin (myoview) scintigraphy for evaluation of ischaemic heart disease. Ir Med J. 1999 Nov-Dec;92(7):437-8. PubMed PMID: 10967869. 6: Migra M, Knazeje M, Ochodnicky M, Kovar F, Lacko A, Mokan M. The detection of early myocardial changes in asymptomatic diabetic individuals by 99mTc - Myoview gated-SPET and heart rate variability measurement. Bratisl Lek Listy. 2014;115(4):216-20. PubMed PMID: 24797596. 7: Khairallah FS, Joyce JM, Myers DT, Organist M. Detection of breast carcinoma in a man on dual-isotope Tl-201 and Tc-99m Myoview myocardial perfusion imaging. Clin Nucl Med. 2002 Oct;27(10):743-4. PubMed PMID: 12352125. 8: Fröberg AC, Valkema R, Bonjer HJ, Krenning EP. 99mTc-tetrofosmin or 99mTc-sestamibi for double-phase parathyroid scintigraphy? Eur J Nucl Med Mol Imaging. 2003 Feb;30(2):193-6. Epub 2002 Nov 23. PubMed PMID: 12552335. 9: Takahashi N, Reinhardt CP, Marcel R, Leppo JA. Myocardial uptake of 99mTc-tetrofosmin, sestamibi, and 201Tl in a model of acute coronary reperfusion. Circulation. 1996 Nov 15;94(10):2605-13. PubMed PMID: 8921807. 10: Fuente A, Zanca R, Boni R, Cataldi AG, Sollini M, Lazzeri E, Mariani G, Erba PA. Miniaturized Radiochemical Purity Testing for (99m)Tc-HMPAO, (99m)Tc-HMDP, and (99m)Tc-Tetrofosmin. J Nucl Med Technol. 2017 Sep;45(3):236-240. doi: 10.2967/jnmt.115.154484. Epub 2017 Jul 13. PubMed PMID: 28705928. 11: Clements IP, Garcia EV, Chen J, Folks RD, Butler J, Jacobson AF. Quantitative iodine-123-metaiodobenzylguanidine (MIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: Development and validation of automated procedures in conjunction with technetium-99m tetrofosmin myocardial perfusion SPECT. J Nucl Cardiol. 2016 Jun;23(3):425-35. doi: 10.1007/s12350-015-0097-4. Epub 2015 Mar 19. PubMed PMID: 25788403. 12: Fukuchi K, Ono Y, Nakahata Y, Okada Y, Hayashida K, Ishida Y. Visualization of interscapular brown adipose tissue using (99m)Tc-tetrofosmin in pediatric patients. J Nucl Med. 2003 Oct;44(10):1582-5. PubMed PMID: 14530470. 13: Esteves FP, Galt JR, Folks RD, Verdes L, Garcia EV. Diagnostic performance of low-dose rest/stress Tc-99m tetrofosmin myocardial perfusion SPECT using the 530c CZT camera: quantitative vs visual analysis. J Nucl Cardiol. 2014 Feb;21(1):158-65. doi: 10.1007/s12350-013-9827-7. Epub 2013 Nov 28. PubMed PMID: 24287713. 14: Aessopos A, Tsironi M, Vassiliadis I, Farmakis D, Fountos A, Voskaridou E, Perakis A, Defteraios S, Loutradi A, Loukopoulos D. Exercise-induced myocardial perfusion abnormalities in sickle beta-thalassemia: Tc-99m tetrofosmin gated SPECT imaging study. Am J Med. 2001 Oct 1;111(5):355-60. PubMed PMID: 11583637. 15: Mouden M, Rijkee KS, Schreuder N, Timmer JR, Jager PL. Influence of proton-pump inhibitors on stomach wall uptake of 99mTc-tetrofosmin in cadmium-zinc-telluride SPECT myocardial perfusion imaging. Nucl Med Commun. 2015 Feb;36(2):143-7. doi: 10.1097/MNM.0000000000000222. PubMed PMID: 25356621. 16: Mizunobu M, Sakai J, Sasao H, Murai H, Fujiwara H. Assessment of left ventricular systolic and diastolic function using ECG-gated technetium-99m tetrofosmin myocardial perfusion SPECT. Int Heart J. 2013;54(4):212-5. PubMed PMID: 23924933. 17: Alexiou GA, Zikou A, Tsiouris S, Goussia A, Kosta P, Papadopoulos A, Voulgaris S, Tsekeris P, Kyritsis AP, Fotopoulos AD, Argyropoulou MI. Comparison of diffusion tensor, dynamic susceptibility contrast MRI and (99m)Tc-Tetrofosmin brain SPECT for the detection of recurrent high-grade glioma. Magn Reson Imaging. 2014 Sep;32(7):854-9. doi: 10.1016/j.mri.2014.04.013. Epub 2014 Apr 24. PubMed PMID: 24848292. 18: Matsunari I, Fujino S, Taki J, Senma J, Aoyama T, Wakasugi T, Hirai J, Saga T, Yamamoto S, Tonami N. Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: comparison with rest-redistribution thallium-201. J Am Coll Cardiol. 1997 May;29(6):1226-33. PubMed PMID: 9137217. 19: Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M. Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: comparison with thallium-201 imaging. J Nucl Med. 1998 May;39(5):802-6. PubMed PMID: 9591579. 20: Schinkel AF, Elhendy A, van Domburg RT, Bax JJ, Roelandt JR, Poldermans D. Prognostic value of dobutamine-atropine stress (99m)Tc-tetrofosmin myocardial perfusion SPECT in patients with known or suspected coronary artery disease. J Nucl Med. 2002 Jun;43(6):767-72. PubMed PMID: 12050321.