CDD-1115 is a potent and BMPR2-selective kinase inhibitor. CDD-1115 Selectively Inhibits BMPR2 with Kiapp values for CDD-1115 (6.2 ± 1.3 nM). CDD-1115 exhibited superior selectivity and potency IC50 of 1.8 nM selectivity over BMPR2 among all other TGFβ family kinases. In this assay, CDD-1115 showed weak inhibition (>250 nM) of ALK1 and ALK2 (>100-fold over BMPR2) and poor inhibition (>1000 nM) of ALK3, ALK5, ALK6, and TGFBR2 (>555-fold over BMPR2) and was inactive in inhibiting ALK4, ACVR2A, and ACVR2B.
MedKoo Cat#: 122678
Name: CDD-1115
CAS#: N/A
Chemical Formula: C32H30N6O3
Exact Mass: 546.2400
Molecular Weight: 546.63
Elemental Analysis: C, 70.31; H, 5.53; N, 15.37; O, 8.78
The following data is based on the product molecular weight 546.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
