Synonym
Spectinomycin Free Base; M141; M 141; M-141
IUPAC/Chemical Name
4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-
InChi Key
UNFWWIHTNXNPBV-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3
SMILES Code
O=C1CC(C)OC2OC3C(C(NC)C(O)C(NC)C3O)OC21O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Holloway WJ. Spectinomycin. Med Clin North Am. 1982 Jan;66(1):169-73. PMID: 6460907.
2: Gomes J, Menawat AS. Fed-batch bioproduction of spectinomycin. Adv Biochem Eng Biotechnol. 1998;59:1-46. doi: 10.1007/BFb0102295. PMID: 9435459.
3: Riedel S, Vijayakumar D, Berg G, Kang AD, Smith KP, Kirby JE. Evaluation of apramycin against spectinomycin-resistant and -susceptible strains of Neisseria gonorrhoeae. J Antimicrob Chemother. 2019 May 1;74(5):1311-1316. doi: 10.1093/jac/dkz012. PMID: 30689929; PMCID: PMC6477976.
4: McCormack WM, Finland M. Drugs five years later. Spectinomycin. Ann Intern Med. 1976 Jun;84(6):712-6. doi: 10.7326/0003-4819-84-6-712. PMID: 132888.
5: Ison CA, Littleton K, Shannon KP, Easmon CS, Phillips I. Spectinomycin resistant gonococci. Br Med J (Clin Res Ed). 1983 Dec 17;287(6408):1827-9. doi: 10.1136/bmj.287.6408.1827. PMID: 6231077; PMCID: PMC1550036.
6: Rosenbrook W Jr. Chemistry of spectinomycin. Jpn J Antibiot. 1979 Dec;32 Suppl:S211-27. PMID: 162066.
7: Centers for Disease Control (CDC). Spectinomycin-resistant Neisseria gonorrhoeae--worldwide. MMWR Morb Mortal Wkly Rep. 1982 Dec 3;31(47):632, 637-8. PMID: 6218390.
8: Thornsberry C, Jaffee H, Brown ST, Edwards T, Biddle JW, Thompson SE. Spectinomycin-resistant Neisseria gonorrhoeae. JAMA. 1977 May 30;237(22):2405-6. PMID: 140251.
9: Song S, Jiang M, Yao J, Liu H, Dai X, Wang G. Alkaline-thermal pretreatment of spectinomycin mycelial residues: Insights on anaerobic biodegradability and the fate of antibiotic resistance genes. Chemosphere. 2020 Dec;261:127821. doi: 10.1016/j.chemosphere.2020.127821. Epub 2020 Jul 29. PMID: 32750621.
10: Hussein SA, Salman BI, Ali MFB, Marzouq MA. Development of sensitive benzofurazan-based spectrometric methods for analysis of spectinomycin in vials and human biological samples. Luminescence. 2019 Dec;34(8):895-902. doi: 10.1002/bio.3688. Epub 2019 Aug 5. PMID: 31379072.
