Synonym
Itavastatin; NK 104; NK104; NK-104; P 872441; P872441; P-872441; Pitavastatin; Zypitamag
IUPAC/Chemical Name
6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (S-(R*,S*-(E)))-
InChi Key
VGYFMXBACGZSIL-MCBHFWOFSA-N
InChi Code
InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1
SMILES Code
O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1c3ccc(F)cc3)C4CC4)CC(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
421.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shang D, Deng S, Yao Z, Wang Z, Ni X, Zhang M, Hu J, Lu H, Zhu X, Huang W, Qiu C, Wen Y. The effect of food on the pharmacokinetic properties and bioequivalence of two formulations of pitavastatin calcium in healthy Chinese male subjects. Xenobiotica. 2016 Jan;46(1):34-9. doi: 10.3109/00498254.2015.1046153. Epub 2015 Jul 17. PubMed PMID: 26186644.
2: Luo Z, Zhang Y, Gu J, Feng P, Wang Y. Pharmacokinetic Properties of Single- and Multiple-Dose Pitavastatin Calcium Tablets in Healthy Chinese Volunteers. Curr Ther Res Clin Exp. 2015 Mar 3;77:52-7. doi: 10.1016/j.curtheres.2015.02.001. eCollection 2015 Dec. PubMed PMID: 26082816; PubMed Central PMCID: PMC4460194.
3: Zhao J, Yan HM, Li Y, Wang J, Han L, Wang ZH, Tang MX, Zhang W, Zhang Y, Zhong M. Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia. J Zhejiang Univ Sci B. 2015 May;16(5):380-7. doi: 10.1631/jzus.B1400181. PubMed PMID: 25990055; PubMed Central PMCID: PMC4432990.
4: Yee LL, Wright EA. Pitavastatin calcium: clinical review of a new antihyperlipidemic medication. Clin Ther. 2011 Aug;33(8):1023-42. doi: 10.1016/j.clinthera.2011.07.011. Epub 2011 Aug 4. Review. PubMed PMID: 21816477.
5: Yan HM, Zhao J, Ma DZ, Wang H, Wang J, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M. The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia. Expert Opin Pharmacother. 2011 Jul;12(10):1463-71. doi: 10.1517/14656566.2011.583238. PubMed PMID: 21651447.
6: Hussar DA, Christian ME. New drugs: pitavastatin calcium, vigabatrin, and romidepsin. J Am Pharm Assoc (2003). 2010 Jul-Aug;50(4):548-51. doi: 10.1331/JAPhA.2010.10530. PubMed PMID: 20621877.
