MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 414034 | Name: Eperisone Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eperisone Free Base is an antispasmodic drug. Eperisone acts by relaxing both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.

Chemical Structure

Eperisone Free Base
Eperisone Free Base
CAS#64840-90-0 (free base)

Theoretical Analysis

MedKoo Cat#: 414034

Name: Eperisone Free Base

CAS#: 64840-90-0 (free base)

Chemical Formula: C17H25NO

Exact Mass: 259.1936

Molecular Weight: 259.39

Elemental Analysis: C, 78.72; H, 9.71; N, 5.40; O, 6.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
64840-90-0 (free base) 56839-43-1 (HCl)
Synonym
Eperisone Free Base; BRN1246496; BRN-1246496; BRN 1246496
IUPAC/Chemical Name
1-Propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-
InChi Key
SQUNAWUMZGQQJD-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H25NO/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18/h7-10,14H,3-6,11-13H2,1-2H3
SMILES Code
O=C(C1=CC=C(CC)C=C1)C(C)CN2CCCCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 259.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Park KH, Lee SC, Yuk JE, Kim SR, Lee JH, Park JW. Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing. Allergy Asthma Immunol Res. 2019 Mar;11(2):231-240. doi: 10.4168/aair.2019.11.2.231. PMID: 30661315; PMCID: PMC6340802. 2: Shin B, Yoon SY, Lee JH, Won HK, An J, Kang Y, Song WJ, Kim TB, Cho YS, Moon HB, Kwon HS. Clinical characteristics of eperisone-induced immediate-type hypersensitivity. Asian Pac J Allergy Immunol. 2020 Dec;38(4):279-285. doi: 10.12932/AP-211018-0420. PMID: 30903996. 3: Bavage S, Durg S, Ali Kareem S, Dhadde SB. Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. Pharmacol Rep. 2016 Oct;68(5):903-12. doi: 10.1016/j.pharep.2016.05.003. Epub 2016 Jun 29. PMID: 27371896. 4: Lee HJ, Ha ES, Lee Y, Ha DC, Choi YW, Baek IH, Kim MS. Pharmacokinetic and bioequivalence study of sugar-coated and film-coated eperisone tablets in healthy subjects: A randomized, open-label, three-way, reference-replicated crossover study. Int J Clin Pharmacol Ther. 2019 Jan;57(1):55-62. doi: 10.5414/CP203346. PMID: 30415650. 5: Pinzon RT, Wijaya VO, Paramitha D, Bagaskara RR. Effects of Eperisone Hydrochloride and Non-Steroid Anti-Inflammatory Drugs (NSAIDs) for Acute Non- Specific Back Pain with Muscle Spasm: A Prospective, Open-Label Study. Drug Healthc Patient Saf. 2020 Nov 16;12:221-228. doi: 10.2147/DHPS.S278467. PMID: 33235514; PMCID: PMC7678690. 6: Ahmed K, Shoaib MH, Yousuf RI, Siddiqui F, Qazi F, Iftikhar J, Ahmed FR, Nasiri MI. Comparative pharmacokinetics of osmotic-controlled and immediate- release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method. Sci Rep. 2020 Feb 5;10(1):1867. doi: 10.1038/s41598-020-58801-1. PMID: 32024955; PMCID: PMC7002734. 7: Yamagiwa T, Morita S, Amino M, Miura N, Saito T, Inokuchi S. Serum concentration of eperisone hydrochloride correlates with QT interval. Am J Emerg Med. 2014 Jan;32(1):75-7. doi: 10.1016/j.ajem.2013.09.006. Epub 2013 Oct 15. PMID: 24135462. 8: Balaraddiyavar N, Bhushan A, Kotinatot BC, Huggi G. Eperisone hydrochloride- induced maculopapular rash. Indian J Pharmacol. 2016 Sep-Oct;48(5):604-605. doi: 10.4103/0253-7613.190765. PMID: 27721553; PMCID: PMC5051261. 9: Bresolin N, Zucca C, Pecori A. Efficacy and tolerability of eperisone and baclofen in spastic palsy: a double-blind randomized trial. Adv Ther. 2009 May;26(5):563-73. doi: 10.1007/s12325-009-0031-8. Epub 2009 May 20. PMID: 19458926. 10: Yoo HH, Kim NS, Kim MJ, Shin D, Shin JG, Kim DH. Enantioselective carbonyl reduction of eperisone in human liver microsomes. Xenobiotica. 2011 Sep;41(9):758-63. doi: 10.3109/00498254.2011.576277. Epub 2011 May 31. PMID: 21623702.