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MedKoo Cat#: 463221 | Name: Eperisone hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eperisone hydrochloride is a compound used in the treatment of musculoskeletal disorders as a muscle relaxant via blocking of calcium channels.

Chemical Structure

Eperisone hydrochloride
Eperisone hydrochloride
CAS#56839-43-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 463221

Name: Eperisone hydrochloride

CAS#: 56839-43-1 (HCl)

Chemical Formula: C17H26ClNO

Exact Mass: 295.1703

Molecular Weight: 295.85

Elemental Analysis: C, 69.02; H, 8.86; Cl, 11.98; N, 4.73; O, 5.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
64840-90-0 (free base) 56839-43-1 (HCl)
Synonym
Eperisone hydrochloride; Eperisone HCl; Myonal; Mional; E 0646; E0646; E-0646; E-646; E646; E 646;
IUPAC/Chemical Name
1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one hydrochloride
InChi Key
GTAXGNCCEYZRII-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H25NO.ClH/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18;/h7-10,14H,3-6,11-13H2,1-2H3;1H
SMILES Code
CCc1ccc(C(C(CN2CCCCC2)C)=O)cc1.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 295.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Prajapati P, Radadiya V, Shah S. Failure Mode Critical Effect Analysis and Design of Experiment-Based Robust Chromatographic Method for Simultaneous Estimation Lornoxicam and Eperisone Hydrochloride. J Chromatogr Sci. 2020 Oct 26;58(10):929-939. doi: 10.1093/chromsci/bmaa064. PMID: 32887996. 2: Cui D, Liu Y, Jin L, Hu L, Cao L. A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. Medicine (Baltimore). 2020 Aug 7;99(32):e21634. doi: 10.1097/MD.0000000000021634. PMID: 32769929. 3: Ota K, Fukui K, Nakamura E, Oka M, Ota K, Sakaue M, Sano Y, Takasu A. Effect of Shakuyaku-kanzo-to in patients with muscle cramps: A systematic literature review. J Gen Fam Med. 2020 Feb 16;21(3):56-62. doi: 10.1002/jgf2.302. PMID: 32489757; PMCID: PMC7260166. 4: Lee HJ, Ha ES, Lee Y, Ha DC, Choi YW, Baek IH, Kim MS. Pharmacokinetic and bioequivalence study of sugar-coated and film-coated eperisone tablets in healthy subjects: A randomized, open-label, three-way, reference-replicated crossover study. Int J Clin Pharmacol Ther. 2019 Jan;57(1):55-62. doi: 10.5414/CP203346. PMID: 30415650. 5: Rabbani G, Baig MH, Lee EJ, Cho WK, Ma JY, Choi I. Biophysical Study on the Interaction between Eperisone Hydrochloride and Human Serum Albumin Using Spectroscopic, Calorimetric, and Molecular Docking Analyses. Mol Pharm. 2017 May 1;14(5):1656-1665. doi: 10.1021/acs.molpharmaceut.6b01124. Epub 2017 Apr 17. PMID: 28380300. 6: Ryu JH, Kim JI, Kim HS, Noh GJ, Lee KT, Chung EK. Pharmacokinetic Interactions Between Pelubiprofen and Eperisone Hydrochloride: A Randomized, Open-label, Crossover Study of Healthy Korean Men. Clin Ther. 2017 Jan;39(1):138-149. doi: 10.1016/j.clinthera.2016.11.020. Epub 2016 Dec 15. PMID: 27989618. 7: Balaraddiyavar N, Bhushan A, Kotinatot BC, Huggi G. Eperisone hydrochloride- induced maculopapular rash. Indian J Pharmacol. 2016 Sep-Oct;48(5):604-605. doi: 10.4103/0253-7613.190765. PMID: 27721553; PMCID: PMC5051261. 8: Miki Y, Washio K, Masaki T, Nakata K, Fukunaga A, Nishigori C. A case of eperisone hydrochloride-induced anaphylaxis: A true type I reaction? Allergol Int. 2017 Jan;66(1):152-153. doi: 10.1016/j.alit.2016.07.004. Epub 2016 Aug 17. PMID: 27544644. 9: Takao Y, Takaoka Y, Sugano A, Sato H, Motoyama Y, Ohta M, Nishimoto T, Mizobuchi S. Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang) as Treatment of Painful Muscle Cramps in Patients with Lumbar Spinal Stenosis and Its Minimum Effective Dose. Kobe J Med Sci. 2015 Apr 4;61(5):E132-7. PMID: 27363396. 10: Tian G, Shen MR, Jiang WG, Xie FR, Wei WW. [Case-control study on spinal leveraging manipulation and medicine for the treatment of degenerative scoliosis]. Zhongguo Gu Shang. 2015 Jun;28(6):508-11. Chinese. PMID: 26255473. 11: Locatelli M, Cifelli R, Di Legge C, Barbacane RC, Costa N, Fresta M, Celia C, Capolupo C, Di Marzio L. Simultaneous determination of eperisone hydrochloride and paracetamol in mouse plasma by high performance liquid chromatography-photodiode array detector. J Chromatogr A. 2015 Apr 3;1388:79-86. doi: 10.1016/j.chroma.2015.02.008. Epub 2015 Feb 11. PMID: 25704771. 12: Vidot H, Carey S, Allman-Farinelli M, Shackel N. Systematic review: the treatment of muscle cramps in patients with cirrhosis. Aliment Pharmacol Ther. 2014 Aug;40(3):221-32. doi: 10.1111/apt.12827. Epub 2014 Jun 18. PMID: 24942957. 13: Yue YS, Wang XD, Xie B, Li ZH, Chen BL, Wang XQ, Zhu Y. Sling exercise for chronic low back pain: a systematic review and meta-analysis. PLoS One. 2014 Jun 11;9(6):e99307. doi: 10.1371/journal.pone.0099307. PMID: 24919119; PMCID: PMC4053356. 14: Khanage SG, Mohite PB, Jadhav S. Development and Validation of UV-Visible Spectrophotometric Method for Simultaneous Determination of Eperisone and Paracetamol in Solid Dosage Form. Adv Pharm Bull. 2013;3(2):447-51. doi: 10.5681/apb.2013.073. Epub 2013 Aug 20. PMID: 24312876; PMCID: PMC3848213. 15: Yamagiwa T, Morita S, Amino M, Miura N, Saito T, Inokuchi S. Serum concentration of eperisone hydrochloride correlates with QT interval. Am J Emerg Med. 2014 Jan;32(1):75-7. doi: 10.1016/j.ajem.2013.09.006. Epub 2013 Oct 15. PMID: 24135462. 16: Kim MJ, Lim HS, Noh YH, Kim YH, Choi HY, Park KM, Kim SE, Bae KS. Pharmacokinetic interactions between eperisone hydrochloride and aceclofenac: a randomized, open-label, crossover study of healthy Korean men. Clin Ther. 2013 Oct;35(10):1528-35. doi: 10.1016/j.clinthera.2013.08.012. Epub 2013 Sep 16. PMID: 24050970. 17: Takeuchi A, Kuroki Y, Iitsuka F, Iita K, Watanabe A, Hatano Y, Endo Y, Mizutani T, Yoshioka T. [Survey of the current conditions in acute poisoning due to antispasmodic agents--special reference to eperisone hydrochloride and afloqualone]. Chudoku Kenkyu. 2011 Sep;24(3):259-64. Japanese. PMID: 22232844. 18: Chandanwale AS, Chopra A, Goregaonkar A, Medhi B, Shah V, Gaikwad S, Langade DG, Maroli S, Mehta SC, Naikwadi A, Pawar DR. Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: a randomized, double-blind, placebo-controlled trial. J Postgrad Med. 2011 Oct-Dec;57(4):278-85. doi: 10.4103/0022-3859.90076. PMID: 22120855. 19: Melilli B, Piazza C, Vitale DC, Marano MR, Pecori A, Mattana P, Volsi VL, Iuculano C, Cardì F, Drago F. Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry. Eur J Drug Metab Pharmacokinet. 2011 Jun;36(2):71-8. doi: 10.1007/s13318-011-0034-0. Epub 2011 Mar 30. PMID: 21448778. 20: Yamagiwa T, Amino M, Morita S, Yamamoto R, Saito T, Inokuchi S. A case of torsades de pointes induced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine. Clin Toxicol (Phila). 2010 Feb;48(2):149-52. doi: 10.3109/15563650903524126. PMID: 20199131.