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MedKoo Cat#: 414015 | Name: Enecadin Free Base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Enecadin Free Base is a voltage-dependent sodium and calcium channel blocker. Enecadin is a neuroprotective agent demonstrated efficacy in animal models of ischemic injury of brain, spinal cord and retina. Enecadin was undergoing phase II development in stroke with PAION in Germany. Enecadin development has been discontinued.

Chemical Structure

Enecadin Free Base
Enecadin Free Base
CAS#259525-01-4 (free base)

Theoretical Analysis

MedKoo Cat#: 414015

Name: Enecadin Free Base

CAS#: 259525-01-4 (free base)

Chemical Formula: C21H28FN3O

Exact Mass: 357.2216

Molecular Weight: 357.47

Elemental Analysis: C, 70.56; H, 7.90; F, 5.31; N, 11.76; O, 4.48

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 950.00 2 Weeks
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Related CAS #
259525-01-4 (free base) 178429-67-9 (HCl)
Synonym
Enecadin Free Base; Enecadina; Enecadine; Enecadinum; NS7; NS-7; NS 7; ZK228326; ZK-228326; ZK 228326
IUPAC/Chemical Name
4-(4-Fluorophenyl)-2-methyl-6-((5-(piperidin-1-yl)pentyl)oxy)pyrimidine
InChi Key
SZSHJTJCJOWMHM-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H28FN3O/c1-17-23-20(18-8-10-19(22)11-9-18)16-21(24-17)26-15-7-3-6-14-25-12-4-2-5-13-25/h8-11,16H,2-7,12-15H2,1H3
SMILES Code
CC1=NC(OCCCCCN2CCCCC2)=CC(C3=CC=C(F)C=C3)=N1
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid Fluid Choice and Clinical Outcomes in Pediatric Sepsis: A Matched Retrospective Cohort Study. J Pediatr. 2017 Mar;182:304-310.e10. doi: 10.1016/j.jpeds.2016.11.075. Epub 2017 Jan 4. PMID: 28063688; PMCID: PMC5525152. 2: Shi E, Kazui T, Jiang X, Washiyama N, Suzuki K, Yamashita K, Terada H. NS-7, a novel Na+/Ca2+ channel blocker, prevents neurologic injury after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg. 2005 Feb;129(2):364-71. doi: 10.1016/j.jtcvs.2004.05.006. PMID: 15678048. 3: Nonaka K, Tsujioka T, Tougou K, Mukai H. Pharmacokinetics of the new pyrimidine derivative NS-7, a novel Na+/Ca2+ channel blocker. 1st communication: plasma concentrations and excretions after a single intravenous 14C-NS-7 injection to rats, dogs and monkeys. Arzneimittelforschung. 2003;53(9):612-20. doi: 10.1055/s-0031-1297157. PMID: 14558434. 4: Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011 Dec 23;147(7):1615-27. doi: 10.1016/j.cell.2011.11.027. PMID: 22196735; PMCID: PMC3262167. 5: Janulaitiene M, Paliulyte V, Grinceviciene S, Zakareviciene J, Vladisauskiene A, Marcinkute A, Pleckaityte M. Prevalence and distribution of Gardnerella vaginalis subgroups in women with and without bacterial vaginosis. BMC Infect Dis. 2017 Jun 5;17(1):394. doi: 10.1186/s12879-017-2501-y. PMID: 28583109; PMCID: PMC5460423. 6: Oka M, Itoh Y, Ukai Y, Kimura K. Blockade by NS-7, a neuroprotective compound, of both L-type and P/Q-type Ca2+ channels involving depolarization- stimulated nitric oxide synthase activity in primary neuronal culture. J Neurochem. 1999 Mar;72(3):1315-22. doi: 10.1046/j.1471-4159.1999.0721315.x. PMID: 10037505. 7: Katsumata T, Muramatsu H, Nakamura H, Nishiyama Y, Aoki Y, Katayama Y. Neuroprotective effect of NS-7, a novel Na+ and Ca2+ channel blocker, in a focal ischemic model in the rat. Brain Res. 2003 Apr 18;969(1-2):168-74. doi: 10.1016/s0006-8993(03)02296-0. PMID: 12676377. 8: Singh R, Ramsuran V, Mitchev N, Niehaus AJ, Han KSS, Osman F, Ngcapu S, Karim SA, Rompalo A, Garrett N, Mlisana K. Assessing a diagnosis tool for bacterial vaginosis. Eur J Clin Microbiol Infect Dis. 2020 Aug;39(8):1481-1485. doi: 10.1007/s10096-020-03862-3. Epub 2020 Mar 20. PMID: 32193689. 9: Sopala M, Danysz W, Quack G. Neuroprotective effects of NS-7, voltage-gated Na+/Ca2+ channel blocker in a rodent model of transient focal ischaemia. Neurotox Res. 2002 Nov-Dec;4(7-8):655-661. doi: 10.1080/1029842021000045462. PMID: 12709303. 10: Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR. Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H547-H556. doi: 10.1152/ajpheart.00307.2020. Epub 2020 Jul 31. PMID: 32734819; PMCID: PMC7509270.

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