MedKoo Cat#: 562468 | Name: AZ3976
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ3976 is an inhibitor of plasminogen activator inhibitor type 1 (PAI-1).

Chemical Structure

AZ3976
AZ3976
CAS#1418747-15-5

Theoretical Analysis

MedKoo Cat#: 562468

Name: AZ3976

CAS#: 1418747-15-5

Chemical Formula: C15H19N5O3

Exact Mass: 317.1488

Molecular Weight: 317.34

Elemental Analysis: C, 56.77; H, 6.03; N, 22.07; O, 15.12

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 2,150.00 2 Weeks
500mg USD 3,850.00 2 Weeks
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Related CAS #
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Synonym
AZ3976; AZ-3976; AZ 3976;
IUPAC/Chemical Name
1-Boc-3-(4-Oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-azetidine
InChi Key
CKUDSTVQYFRZJW-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H19N5O3/c1-15(2,3)23-14(22)20-7-9(8-20)17-13-18-11-10(12(21)19-13)5-4-6-16-11/h4-6,9H,7-8H2,1-3H3,(H2,16,17,18,19,21)
SMILES Code
O=C1C2=CC=CN=C2N=C(NC3CN(C(OC(C)(C)C)=O)C3)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cazzolli G, Wang F, a Beccara S, Gershenson A, Faccioli P, Wintrode PL. Serpin latency transition at atomic resolution. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15414-9. doi: 10.1073/pnas.1407528111. Epub 2014 Oct 13. PubMed PMID: 25313058; PubMed Central PMCID: PMC4217474. 2: Fjellström O, Deinum J, Sjögren T, Johansson C, Geschwindner S, Nerme V, Legnehed A, McPheat J, Olsson K, Bodin C, Paunovic A, Gustafsson D. Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem. 2013 Jan 11;288(2):873-85. doi: 10.1074/jbc.M112.371732. Epub 2012 Nov 15. PubMed PMID: 23155046; PubMed Central PMCID: PMC3543036.