Synonym
Ethaverine; Ethylpapaverine; Barbonin; Barbonine; Dyscural; Ethquinol; Perparine; Perperine;
IUPAC/Chemical Name
6,7-Diethoxy-1-(3,4-diethoxybenzyl)isoquinoline
InChi Key
ZOWYFYXTIWQBEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-12,14-16H,5-8,13H2,1-4H3
SMILES Code
CCOC1=CC=C(C=C1OCC)CC2=NC=CC3=C2C=C(OCC)C(OCC)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
395.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jiang W, Chen H, Tai Z, Li T, Luo L, Tong Z, Zhu W. Apigenin and Ethaverine Hydrochloride Enhance Retinal Vascular Barrier In Vitro and In Vivo. Transl Vis Sci Technol. 2020 May 11;9(6):8. doi: 10.1167/tvst.9.6.8. PMID: 32821505; PMCID: PMC7409011.
2: Wang Y, Rosenberg RL. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. PMID: 1658607.
3: Lee SS, Lee JJ, Cheong MJ, Kim YH, Kim Y, Yun YP, Lee CK, Lee MK. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40. doi: 10.1248/bpb.24.838. PMID: 11456127.
4: Shin JS, Lee JJ, Kim Y, Lee CK, Yun YP, Lee MK. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. doi: 10.1248/bpb.24.103. PMID: 11201237.
5: Frankel EB. Letter: Ethaverine therapy for multiple leiomyomas. Arch Dermatol. 1974 Aug;110(2):296. doi: 10.1001/archderm.1974.01630080084028. PMID: 4852780.
6: Suh BC, Kim KT. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. doi: 10.1016/0006-2952(94)90399-9. PMID: 8161356.
7: Trainor FS, Phillips RE, Michie DD, Zellner SR, Hogan L Jr, Chubb JM. Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication. Angiology. 1986 May;37(5):343-51. doi: 10.1177/000331978603700502. PMID: 3521401.
8: DEGENHARDT DP, HODGKINSON R. Ethaverine in the treatment of angina pectoris. Br Heart J. 1954 Apr;16(2):142-6. doi: 10.1136/hrt.16.2.142. PMID: 13160265; PMCID: PMC479509.
9: Eppelsheim C, Aubeck R, Hampp N, Bräuchle C. Determination of ethaverine and papaverine using ion-selective electrodes. Analyst. 1991 Oct;116(10):1001-3. doi: 10.1039/an9911601001. PMID: 1801598.
10: Papaverine and ethaverine studies. FDA Drug Bull. 1979 Nov;9(5):26. PMID: 510835.
