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MedKoo Cat#: 562320 | Name: Ethaverine HBr
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ethaverine HBr is an inhibitor of the parasympathetic nervous system actions.

Chemical Structure

Ethaverine HBr
Ethaverine HBr
CAS#855701-63-2 (HBr)

Theoretical Analysis

MedKoo Cat#: 562320

Name: Ethaverine HBr

CAS#: 855701-63-2 (HBr)

Chemical Formula: C24H30BrNO4

Exact Mass: 0.0000

Molecular Weight: 476.41

Elemental Analysis: C, 60.51; H, 6.35; Br, 16.77; N, 2.94; O, 13.43

Price and Availability

Size Price Availability Quantity
5mg USD 355.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
855701-63-2 (HBr) 985-13-7 (HCl) 486-47-5 (free base)
Synonym
Ethaverine HBr; Ethaverine Hydrobromide;
IUPAC/Chemical Name
1-[(3,4-Diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline hydrobromide
InChi Key
YRTGNDNAEHCMPR-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29NO4.BrH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-12,14-16H,5-8,13H2,1-4H3;1H
SMILES Code
CCOC1=CC2=C(C=C1OCC)C=CN=C2CC3=CC=C(OCC)C(OCC)=C3.[H]Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 476.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Prasad KR, Gholap SL. Stereoselective total synthesis of bioactive styryllactones (+)-goniofufurone, (+)7-epi-goniofufurone, (+)-goniopypyrone, (+)-goniotriol, (+)-altholactone, and (-)-etharvensin. J Org Chem. 2008 Jan 4;73(1):2-11. Epub 2007 May 25. PubMed PMID: 17523660. 2: Lee SS, Lee JJ, Cheong MJ, Kim YH, Kim Y, Yun YP, Lee CK, Lee MK. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40. PubMed PMID: 11456127. 3: Shin JS, Lee JJ, Kim Y, Lee CK, Yun YP, Lee MK. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. PubMed PMID: 11201237. 4: Zoraghi R, Kunz S, Gong K, Seebeck T. Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei. J Biol Chem. 2001 Apr 13;276(15):11559-66. Epub 2000 Dec 27. PubMed PMID: 11134002. 5: Kraupp M, Paskutti B, Schön C, Marz R. Inhibition of purine nucleobase transport in human erythrocytes and cell lines by papaverine. Investigation of structure-activity relationship. Biochem Pharmacol. 1994 Jul 5;48(1):41-7. PubMed PMID: 8043029. 6: Suh BC, Kim KT. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. PubMed PMID: 8161356. 7: Girgis EH. Ion-pair reversed-phase liquid chromatographic identification and quantitation of papaverine congeners. J Pharm Sci. 1993 May;82(5):503-5. PubMed PMID: 8360827. 8: Wang Y, Rosenberg RL. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. PubMed PMID: 1658607. 9: Eppelsheim C, Aubeck R, Hampp N, Bräuchle C. Determination of ethaverine and papaverine using ion-selective electrodes. Analyst. 1991 Oct;116(10):1001-3. PubMed PMID: 1801598. 10: Turgeon J, Funck-Brentano C, Gray HT, Roden DM. Improved high-performance liquid chromatographic assay for encainide and its metabolites in human body fluids. J Chromatogr. 1989 May 5;490(1):165-74. PubMed PMID: 2503530. 11: Trainor FS, Phillips RE, Michie DD, Zellner SR, Hogan L Jr, Chubb JM. Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication. Angiology. 1986 May;37(5):343-51. PubMed PMID: 3521401. 12: Lapeyrère X, Gruyer P, Guyot L, Barbe G, Saint-Paul B. [Comparative action of different platelet anti-aggregants in the postoperative period]. Cah Anesthesiol. 1984 Mar;32(2):123-5. French. PubMed PMID: 6529644. 13: Meyer MC, Raghow G, Straughn AB. Plasma levels of ethaverine after oral administration to humans. Biopharm Drug Dispos. 1983 Oct-Dec;4(4):401-4. PubMed PMID: 6661518. 14: Greenslade FC, Scott CK, Newquist KL, Krider KM, Chasin M. Heterogeneity of biochemical actions among vasodilators. J Pharm Sci. 1982 Jan;71(1):94-100. PubMed PMID: 6276530. 15: Prazma J, Biggers WP, Fischer ND. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. PubMed PMID: 7213183. 16: Maier-Lenz H, Ringwelski L, Windorfer A. [A comparative pharmacokinetic study for tablet and suppository formulations of a combination product of caffeine, ethaverine, propyphenazone, paracetamol and phenobarbital (author's transl)]. Arzneimittelforschung. 1981;31(1):105-9. German. PubMed PMID: 7194086. 17: Brodie RR, Chasseaud LF, Walmsley LM, Soegtrop HH, Darragh A, O'Kelly DA. Determination of the antispasmodic agent ethaverine in human plasma by high-performance liquid chromatography. J Chromatogr. 1980 Jun 13;182(3-4):379-86. PubMed PMID: 7391180. 18: Papaverine and ethaverine studies. FDA Drug Bull. 1979 Nov;9(5):26. PubMed PMID: 510835. 19: Lacroix P, Linee P, Le Polles JB. Effects of some coronary vasodilator drugs on collateral hemodynamics after chronic myocardial ischemia in the anesthetized dog: appropriate or inappropriate redistribution? J Pharmacol Exp Ther. 1978 Mar;204(3):645-54. PubMed PMID: 633070. 20: Wuppermann D, Zimmermann F, Friedrich L. [Comparative study on the effects of alprenolol, bunitrolol, ethaverine, oxprenolol, papaverine, practolol, pindolol, pronethalol, propranolol, toliprolol and verapamil on cardiac and bronchial beta-receptors (author's transl)]. Arzneimittelforschung. 1978;28(5):794-8. German. PubMed PMID: 35172.