Synonym
Etidocaine Free Base; Etidocaina; Duranest; Etidocainum; W-19053; W19053; W 19053
IUPAC/Chemical Name
Butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-, (+-)-
InChi Key
VTUSIVBDOCDNHS-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20)
SMILES Code
CCC(N(CC)CCC)C(NC1=C(C)C=CC=C1C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
276.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Oliveira JD, Ribeiro LNM, Rodrigues da Silva GH, Casadei BR, Couto VM, Martinez EF, de Paula E. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharm Res. 2018 Oct 10;35(12):229. doi: 10.1007/s11095-018-2512-4. PMID: 30306273.
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7: Thomas J, Morgan D, Vine J. Metabolism of etidocaine in man. Xenobiotica. 1976 Jan;6(1):39-48. doi: 10.3109/00498257609151610. PMID: 1274369.
8: Sarvela J, Nikki P. Hyaluronidase improves regional ophthalmic anaesthesia with etidocaine. Can J Anaesth. 1992 Nov;39(9):920-4. doi: 10.1007/BF03008340. PMID: 1451220.
9: Wahedi W, Nolte H, Trombitas G, Wehking M. Zur Frage der Aquipotenz von Ropivacain, Bupivacain und Etidocain [The equipotency of ropivacaine, bupivacaine and etidocaine]. Reg Anaesth. 1990 May;13(3):66-72. German. PMID: 2192405.
10: Donoghue R, Doberenz K, Jacobsen PL. Etidocaine hydrochloride in surgical procedures: effects on postoperative analgesia. J Am Dent Assoc. 1990 Apr;120(4):429-32, 434. doi: 10.14219/jada.archive.1990.0129. PMID: 2319066.
