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MedKoo Cat#: 328911 | Name: Etidocaine Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etidocaine Hydrochloride, also known as Duranest and W-19053, is a voltage-gated sodium channel blocking agent used as an anesthetic with prolonged duration of action.

Chemical Structure

Etidocaine Hydrochloride
Etidocaine Hydrochloride
CAS#36637-19-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 328911

Name: Etidocaine Hydrochloride

CAS#: 36637-19-1 (HCl)

Chemical Formula: C17H30ClN2O

Exact Mass: 0.0000

Molecular Weight: 313.89

Elemental Analysis: C, 65.05; H, 9.63; Cl, 11.29; N, 8.92; O, 5.10

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
36637-18-0 (free base) 36637-19-1 (HCl)
Synonym
Etidocaine Hydrochloride; Duranest; Duranest Hydrochloride; Etidocaine HCl; W-19053; W 19053; W19053
IUPAC/Chemical Name
N-(2,6-dimethylphenyl)-2-(ethyl(propyl)-l4-azanyl)butanamide hydrochloride
InChi Key
VLRLCSBNZVEEFY-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H29N2O.ClH/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5;/h9-11,15,19H,6-8,12H2,1-5H3,(H,18,20);1H
SMILES Code
CCC([NH](CC)CCC)C(NC1=C(C)C=CC=C1C)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 36637-19-1 (Etidocaine Hydrochloride) 36637-18-0 (Etidocaine)

Preparing Stock Solutions

The following data is based on the product molecular weight 313.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rood JP. Etidocaine in dentistry. Anesth Prog. 1989 Jul-Oct;36(4-5):190-1. PMID: 2490028; PMCID: PMC2190675. 2: Bacsik CJ, Swift JQ, Hargreaves KM. Toxic systemic reactions of bupivacaine and etidocaine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):18-23. doi: 10.1016/s1079-2104(05)80067-8. PMID: 7614153. 3: Ruetsch YA, Böni T, Borgeat A. From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem. 2001 Aug;1(3):175-82. doi: 10.2174/1568026013395335. PMID: 11895133. 4: Bennett RG, Robins P. Etidocaine, a new local anesthetic. J Dermatol Surg Oncol. 1979 Jul;5(7):551-3. doi: 10.1111/j.1524-4725.1979.tb00714.x. PMID: 458021. 5: Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology. 1979 Oct;51(4):285-7. doi: 10.1097/00000542-197910000-00001. PMID: 484889. 6: Thomas J, Morgan D, Vine J. Metabolism of etidocaine in man. Xenobiotica. 1976 Jan;6(1):39-48. doi: 10.3109/00498257609151610. PMID: 1274369. 7: Munson ES, Tucker WK, Ausinsch B, Malagodi MH. Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys. Anesthesiology. 1975 Apr;42(4):471-8. doi: 10.1097/00000542-197504000-00018. PMID: 1119714. 8: Garcia DG. Etidocaine--a long-acting anesthetic agent. Review of the literature. Anesth Prog. 1982 Jan-Feb;29(1):12-3. PMID: 6954860; PMCID: PMC2515462. 9: Moore DC, Bridenbaugh PO, Bridenbaugh LD, Thompson GE, Balfour RI, Lysons DF. Bupivacaine compared with etidocaine for vaginal delivery. Anesth Analg. 1975 Mar-Apr;54(2):250-6. PMID: 1168435. 10: Morgan DJ, Smyth MP, Thomas J, Vine J. Cyclic metabolites of etidocaine in humans. Xenobiotica. 1977 Jun;7(6):365-75. doi: 10.3109/00498257709035795. PMID: 610053. 11: Willdeck-Lund G, Edström H. Etidocaine in intercostal nerve block for pain relief after thoracotomy; a comparison with bupivacaine. Acta Anaesthesiol Scand Suppl. 1975;60:33-8. doi: 10.1111/j.1399-6576.1975.tb05403.x. PMID: 241197. 12: Oliveira JD, Ribeiro LNM, Rodrigues da Silva GH, Casadei BR, Couto VM, Martinez EF, de Paula E. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharm Res. 2018 Oct 10;35(12):229. doi: 10.1007/s11095-018-2512-4. PMID: 30306273. 13: Malamed SF. Nouveaux anesthésiques [New anesthetics]. Rev Belge Med Dent (1984). 2000;55(1):9-18. French. PMID: 11039279. 14: Stanton-Hicks M, Murphy TM, Bonica JJ, Berges PU, Mather LE, Tucker GT. Effects of peridural block: V. Properties, circulatory effects, and blood levels of etidocaine and lidocaine. Anesthesiology. 1975 Apr;42(4):398-407. PMID: 235229. 15: Sisk AL. Analgesic concerns. J Am Dent Assoc. 1990 Aug;121(2):220. doi: 10.14219/jada.archive.1990.0239. PMID: 2401775. 16: Lund PC, Cwik JC, Gannon RT. Etidocaine (Duranest): a clinical and laboratory evaluation. Acta Anaesthesiol Scand. 1974;18(3):176-88. doi: 10.1111/j.1399-6576.1974.tb00858.x. PMID: 4428937. 17: Sinclair CJ, Scott DB. Comparison of bupivacaine and etidocaine in extradural blockade. Br J Anaesth. 1984 Feb;56(2):147-53. doi: 10.1093/bja/56.2.147. PMID: 6362694. 18: Malagodi MH, Munson ES, Embro WJ. Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys. Br J Anaesth. 1977 Feb;49(2):121-5. doi: 10.1093/bja/49.2.121. PMID: 402143. 19: Stanton-Hicks M, Murphy TM, Bonica JJ, Mather LE, Tucker GT. Effects of extradural block: comparison of the properties, circulatory effects and pharmacokinetics of etidocaine and bupivacaine. Br J Anaesth. 1976 Jun;48(6):575-86. doi: 10.1093/bja/48.6.575. PMID: 952693. 20: Donoghue R, Doberenz K, Jacobsen PL. Etidocaine hydrochloride in surgical procedures: effects on postoperative analgesia. J Am Dent Assoc. 1990 Apr;120(4):429-32, 434. doi: 10.14219/jada.archive.1990.0129. PMID: 2319066.

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