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MedKoo Cat#: 413945 | Name: SQ 32547

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SQ 32547 is a dihydropyrimidine calcium channel antagonist

Chemical Structure

SQ 32547
SQ 32547
CAS#135100-65-1

Theoretical Analysis

MedKoo Cat#: 413945

Name: SQ 32547

CAS#: 135100-65-1

Chemical Formula: C29H32ClF4N3O4S

Exact Mass: 629.1738

Molecular Weight: 630.09

Elemental Analysis: C, 55.28; H, 5.12; Cl, 5.63; F, 12.06; N, 6.67; O, 10.16; S, 5.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SQ32547; SQ-32547; SQ 32547; SQ32,547; SQ-32,547; SQ 32,547
IUPAC/Chemical Name
1,5(2H)-Pyrimidinedicarboxylic acid, 3,6-dihydro-4-methyl-2-thioxo-6-(2-(trifluoromethyl)phenyl)-, 1-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-5-(1-methylethyl)ester, monohydrochloride, (R)-
InChi Key
BKZKQSNXYRNLFD-VQIWEWKSSA-N
InChi Code
InChI=1S/C29H31F4N3O4S.ClH/c1-17(2)39-26(37)24-18(3)34-27(41)36(25(24)22-6-4-5-7-23(22)29(31,32)33)28(38)40-21-12-14-35(15-13-21)16-19-8-10-20(30)11-9-19;/h4-11,17,21,25H,12-16H2,1-3H3,(H,34,41);1H/t25-;/m1./s1
SMILES Code
O=C(N1[C@H](C2=CC=CC=C2C(F)(F)F)C(C(OC(C)C)=O)=C(C)NC1=S)OC3CCN(CC4=CC=C(F)C=C4)CC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 630.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Grover GJ, Dzwonczyk S, McMullen DM, Normandin DE, Parham CS, Sleph PG, Moreland S. Pharmacologic profile of the dihydropyrimidine calcium channel blockers SQ 32,547 and SQ 32,926 [correction of SQ 32,946]. J Cardiovasc Pharmacol. 1995 Aug;26(2):289-94. doi: 10.1097/00005344-199508000-00015. PMID: 7475054. 2: Arun A, Ansari MI, Popli P, Jaiswal S, Mishra AK, Dwivedi A, Hajela K, Konwar R. New piperidine derivative DTPEP acts as dual-acting anti-breast cancer agent by targeting ERα and downregulating PI3K/Akt-PKCα leading to caspase-dependent apoptosis. Cell Prolif. 2018 Dec;51(6):e12501. doi: 10.1111/cpr.12501. Epub 2018 Aug 9. PMID: 30091186; PMCID: PMC6528961. 3: Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, Malley MF. Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents. J Med Chem. 1992 Aug 21;35(17):3254-63. doi: 10.1021/jm00095a023. PMID: 1387168.