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MedKoo Cat#: 413916 | Name: DQ 2556

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DQ 2556 is a recently developed cephalosporin with a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria. I

Chemical Structure

DQ 2556
DQ 2556
CAS#102253-70-3

Theoretical Analysis

MedKoo Cat#: 413916

Name: DQ 2556

CAS#: 102253-70-3

Chemical Formula: C22H19N7O6S2

Exact Mass: 541.0838

Molecular Weight: 541.56

Elemental Analysis: C, 48.79; H, 3.54; N, 18.11; O, 17.73; S, 11.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DQ 2556; DQ-2556; DQ2556
IUPAC/Chemical Name
Pyridinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-4-(5-oxazolyl)-, hydroxide, inner salt, (6R-(6-alpha,7-beta(Z)))-
InChi Key
IWIVCNVLSKNJJS-HOHIPHJJSA-N
InChi Code
InChI=1S/C22H19N7O6S2/c1-34-27-15(13-9-37-22(23)25-13)18(30)26-16-19(31)29-17(21(32)33)12(8-36-20(16)29)7-28-4-2-11(3-5-28)14-6-24-10-35-14/h2-6,9-10,16,20H,7-8H2,1H3,(H3-,23,25,26,30,32,33)/b27-15-/t16-,20-/m0/s1
SMILES Code
O=C1[C@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@]3([H])SCC(C[N+]4=CC=C(C5=CN=CO5)C=C4)=C(C([O-])=O)N13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 541.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanaka M, Otsuki M, Nishino T. In vitro and in vivo activities of DQ-2556 and its mode of action. Antimicrob Agents Chemother. 1992 Dec;36(12):2595-601. doi: 10.1128/aac.36.12.2595. PMID: 1482128; PMCID: PMC245513. 2: Sokol PP. Effect of DQ-2556, a new cephalosporin, on organic ion transport in renal plasma membrane vesicles from the dog, rabbit and rat. J Pharmacol Exp Ther. 1990 Nov;255(2):436-41. PMID: 2147035. 3: Fujimoto T, Watanabe M, Inoue M, Mitsuhashi S. In-vitro antibacterial activity of DQ-2556 and its stability to various beta-lactamases. J Antimicrob Chemother. 1990 Sep;26(3):329-41. doi: 10.1093/jac/26.3.329. PMID: 2228824. 4: Ishida Y, Miyazaki S, Yamaguchi K, Goto S. In vitro and in vivo activity of DQ-2556, a new cephalosporin. Chemotherapy. 1995 Jan-Feb;41(1):5-13. doi: 10.1159/000239318. PMID: 7875022. 5: Shiba K, Yoshida M, Shimada J, Saito A, Matsubayashi K, Hashimoto S, Yoshida K, Osada Y, Sakai O. Effect of probenecid on the pharmacokinetics of DQ-2556, a new 3-quaternary ammonium cephalosporin antibiotic, in humans. Chemotherapy. 1992;38(6):369-75. doi: 10.1159/000239029. PMID: 1288960. 6: Matsubayashi K, Shintani S, Yoshioka M, Tachizawa H. Metabolic disposition of DQ-2556, a new cephalosporin, in rats, rabbits, dogs, and monkeys. Antimicrob Agents Chemother. 1992 May;36(5):966-72. doi: 10.1128/aac.36.5.966. PMID: 1510421; PMCID: PMC188793. 7: Matsubayashi K, Shintani S, Yoshida K, Yamada M, Tachizawa H. Nonlinear pharmacokinetics of DQ-2556, a new 3-quaternary ammonium cephalosporin antibiotic, in rats caused by non-Michaelis-Menten type, dose-dependent renal clearance. J Pharm Sci. 1994 Feb;83(2):186-92. doi: 10.1002/jps.2600830214. PMID: 8169786. 8: Yasuda J, Yamamoto T, Okada H. [Pharmacokinetic and clinical studies on DQ-2556 in the gynecological field]. Jpn J Antibiot. 1993 Jan;46(1):67-74. Japanese. PMID: 8455333. 9: Kato M, Yoshida M, Shimada H, Akahane K, Takayama S. Nephrotoxicity of a new cephalosporin, DQ-2556, in rats. Fundam Appl Toxicol. 1992 May;18(4):532-9. doi: 10.1016/0272-0590(92)90112-u. PMID: 1526365. 10: Fujimoto T, Otani T, Nakajima R, Une T, Osada Y. In vitro activity of DQ-2556, a new cephalosporin. Antimicrob Agents Chemother. 1986 Oct;30(4):611-3. doi: 10.1128/aac.30.4.611. PMID: 3539013; PMCID: PMC176491.