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MedKoo Cat#: 574917 | Name: Triacsin C
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Triacsin C is an inhibitor of long fatty acid acyl-CoA synthetase. It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.

Chemical Structure

Triacsin C
Triacsin C
CAS#76896-80-5

Theoretical Analysis

MedKoo Cat#: 574917

Name: Triacsin C

CAS#: 76896-80-5

Chemical Formula: C11H17N3O

Exact Mass: 207.1372

Molecular Weight: 207.28

Elemental Analysis: C, 63.74; H, 8.27; N, 20.27; O, 7.72

Price and Availability

Size Price Availability Quantity
1mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
FR 900190; Triacsin C; WS 1228A
IUPAC/Chemical Name
2E,4E,7E-undecatrienal, nitrosohydrazone
InChi Key
NKTGCVUIESDXPU-YLEPRARLSA-N
InChi Code
InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+
SMILES Code
CCC/C=C/C/C=C/C=C/C=N/NN=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 207.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Battle D, Qiu X, Alex M, Rivers L, Hamilton JAG, Takayama S, Zhao X. Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity. Cells. 2025 Feb 27;14(5):349. doi: 10.3390/cells14050349. PMID: 40072078; PMCID: PMC11899473. 2: Wu Z, Zhao Q, Hu Z, Jiao D. Lipid droplets deposition in perihematoma tissue is associated with neurological dysfunction after intracerebral hemorrhage. Neuroreport. 2025 Feb 20. doi: 10.1097/WNR.0000000000002136. Epub ahead of print. PMID: 39976011. 3: Murphy CS, Fairfield H, DeMambro VE, Fadel S, Gartner CA, Karam M, Potts C, Rodriguez P, Qiang YW, Hamidi H, Guan X, Vary CPH, Reagan MR. Inhibition of acyl-CoA synthetase long-chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction. Mol Oncol. 2025 Jan 23. doi: 10.1002/1878-0261.13794. Epub ahead of print. PMID: 39853696. 4: Gu W, Zeng B, Zhang Y, Zhao F, Lin X, Wang X, Liu N, Sun F, Zhou F, Zhang S, Dai Y. Acyl-CoA long-chain synthetase 1 (ACSL1) protects the endometrium from excess palmitic acid stress during decidualization. Cell Signal. 2024 Dec;124:111438. doi: 10.1016/j.cellsig.2024.111438. Epub 2024 Sep 27. PMID: 39343116. 5: Lin Y, Zhang X, Wang Y, Yao W. LPCAT2-mediated lipid droplet production supports pancreatic cancer chemoresistance and cell motility. Int Immunopharmacol. 2024 Sep 30;139:112681. doi: 10.1016/j.intimp.2024.112681. Epub 2024 Jul 27. PMID: 39068758. 6: Panina SB, Schweer JV, Zhang Q, Raina G, Hardtke HA, Kim S, Yang W, Siegel D, Zhang YJ. Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells. BMC Biol. 2024 Apr 12;22(1):83. doi: 10.1186/s12915-024-01879-0. PMID: 38609948; PMCID: PMC11015551. 7: Coant N, Rendja K, Bellini L, Flamment M, Lherminier J, Portha B, Codogno P, Le Stunff H. Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced Early Activation of Autophagy in INS-1 Pancreatic β Cells. Cells. 2024 Apr 5;13(7):636. doi: 10.3390/cells13070636. PMID: 38607078; PMCID: PMC11011436. 8: Yao X, Yang C, Jia X, Yu Z, Wang C, Zhao J, Chen Y, Xie B, Zhuang H, Sun C, Li Q, Kang X, Xiao Y, Liu L. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain Behav Immun. 2024 Jul;119:236-250. doi: 10.1016/j.bbi.2024.04.005. Epub 2024 Apr 9. PMID: 38604269. 9: Ma Y, Nenkov M, Berndt A, Abubrig M, Schmidt M, Sandhaus T, Huber O, Clement JH, Lang SM, Chen Y, Gaßler N. The Diagnostic Value of ACSL1, ACSL4, and ACSL5 and the Clinical Potential of an ACSL Inhibitor in Non-Small-Cell Lung Cancer. Cancers (Basel). 2024 Mar 16;16(6):1170. doi: 10.3390/cancers16061170. PMID: 38539505; PMCID: PMC10969076. 10: Xin W, Pan Y, Wei W, Gerner ST, Huber S, Juenemann M, Butz M, Bähr M, Huttner HB, Doeppner TR. TGF-β1 Decreases Microglia-Mediated Neuroinflammation and Lipid Droplet Accumulation in an In Vitro Stroke Model. Int J Mol Sci. 2023 Dec 10;24(24):17329. doi: 10.3390/ijms242417329. PMID: 38139158; PMCID: PMC10743979. 11: Al-Roub A, Akhter N, Al-Rashed F, Wilson A, Alzaid F, Al-Mulla F, Sindhu S, Ahmad R. TNFα induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways. Sci Rep. 2023 Sep 1;13(1):14351. doi: 10.1038/s41598-023-41514-6. PMID: 37658104; PMCID: PMC10474281. 12: Al-Rashed F, Haddad D, Al Madhoun A, Sindhu S, Jacob T, Kochumon S, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R. ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding. iScience. 2023 Jun 15;26(7):107145. doi: 10.1016/j.isci.2023.107145. PMID: 37416456; PMCID: PMC10320618. 13: Tang F, Zhou LY, Li P, Jiao LL, Chen K, Guo YJ, Ding XL, He SY, Dong B, Xu RX, Xiong H, Lei P. Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species. Neurotherapeutics. 2023 Jul;20(4):1154-1166. doi: 10.1007/s13311-023-01382-4. Epub 2023 May 3. PMID: 37133631; PMCID: PMC10457271. 14: Ye W, Wang J, Huang J, He X, Ma Z, Li X, Huang X, Li F, Huang S, Pan J, Jin J, Ling Q, Wang Y, Yu Y, Sun J, Jin J. ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification. Front Med. 2023 Aug;17(4):685-698. doi: 10.1007/s11684-022-0942-1. Epub 2023 May 3. PMID: 37131085. 15: He W, Tran A, Chen CT, Loganathan N, Bazinet RP, Belsham DD. Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons. Mol Cell Endocrinol. 2022 Nov 1;557:111753. doi: 10.1016/j.mce.2022.111753. Epub 2022 Aug 15. PMID: 35981630. 16: Yako T, Otsu W, Nakamura S, Shimazawa M, Hara H. Lipid Droplet Accumulation Promotes RPE Dysfunction. Int J Mol Sci. 2022 Feb 4;23(3):1790. doi: 10.3390/ijms23031790. PMID: 35163712; PMCID: PMC8836556. 17: Bonnet R, Mariault L, Peyron JF. Identification of potentially anti-COVID-19 active drugs using the connectivity MAP. PLoS One. 2022 Jan 27;17(1):e0262751. doi: 10.1371/journal.pone.0262751. PMID: 35085325; PMCID: PMC8794112. 18: Xia H, Zhang Z, You F. Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. Viruses. 2021 Nov 28;13(12):2383. doi: 10.3390/v13122383. PMID: 34960652; PMCID: PMC8708337. 19: Kwon YS, Lee MG, Baek J, Kim NY, Jang H, Kim S. Acyl-CoA synthetase-4 mediates radioresistance of breast cancer cells by regulating FOXM1. Biochem Pharmacol. 2021 Oct;192:114718. doi: 10.1016/j.bcp.2021.114718. Epub 2021 Aug 3. PMID: 34358518. 20: Al-Roub A, Akhter N, Al-Sayyar A, Wilson A, Thomas R, Kochumon S, Al-Rashed F, Al-Mulla F, Sindhu S, Ahmad R. Short Chain Fatty Acid Acetate Increases TNFα- Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis. Int J Mol Sci. 2021 Jul 19;22(14):7683. doi: 10.3390/ijms22147683. PMID: 34299302; PMCID: PMC8304091.