MedKoo Cat#: 562210 | Name: GDC-0339
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GDC-0339 is a bioavailable and efficacious PIM inhibitor for multiple myeloma.

Chemical Structure

GDC-0339
GDC-0339
CAS#1428569-85-0

Theoretical Analysis

MedKoo Cat#: 562210

Name: GDC-0339

CAS#: 1428569-85-0

Chemical Formula: C20H22F3N7OS

Exact Mass: 465.1559

Molecular Weight: 465.49

Elemental Analysis: C, 51.60; H, 4.76; F, 12.24; N, 21.06; O, 3.44; S, 6.89

Price and Availability

Size Price Availability Quantity
5mg USD 850.00 2 Weeks
10mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
GDC-0339; GDC 0339; GDC0339;
IUPAC/Chemical Name
5-Amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide
InChi Key
NHXVGMQFCYBLTL-ZWNOBZJWSA-N
InChi Code
InChI=1S/C20H22F3N7OS/c1-29-20(30-7-5-10(21)13(24)6-8-30)14(9-26-29)27-18(31)16-17(25)32-19(28-16)15-11(22)3-2-4-12(15)23/h2-4,9-10,13H,5-8,24-25H2,1H3,(H,27,31)/t10-,13-/m1/s1
SMILES Code
O=C(C1=C(N)SC(C2=C(F)C=CC=C2F)=N1)NC3=C(N4CC[C@@H](N)[C@H](F)CC4)N(C)N=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 465.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takahashi RH, Wang X, Segraves NL, Wang J, Chang JH, Khojasteh SC, Ma S. CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339. Drug Metab Dispos. 2017 Oct;45(10):1084-1092. doi: 10.1124/dmd.117.076786. Epub 2017 Aug 8. PubMed PMID: 28790146.