UMB298 is a Potent and Selective CBP/P300 Inhibitor with CBP IC50 72 nM and bromodomain 4, BRD4 IC50 5193 nM. UMB298 inhibited MOLM13 cells growth. Moreover, UMB298 reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. Certainly, the results suggest that UMB298 has excellent anti-cancer effect. Not only that, UMB298 displayed 72-fold selectivity for CBP over BRD4 as a selective CBP inhibitor.
MedKoo Cat#: 464586
Name: UMB298
CAS#: 2266569-73-5
Chemical Formula: C27H31ClN4O2
Exact Mass: 478.2136
Molecular Weight: 479.02
Elemental Analysis: C, 67.70; H, 6.52; Cl, 7.40; N, 11.70; O, 6.68
The following data is based on the product molecular weight 479.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
