MedKoo Cat#: 112052 | Name: Pulmatin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pulmatin is an anthraquinone glycoside that inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 18.34 µM) and yeast and rat intestinal α-glucosidase when used at a concentration of 50 µg/ml. It also increases insulin-induced glucose transport by 255% in L6 myotubes.

Chemical Structure

Pulmatin
Pulmatin
CAS#13241-28-6

Theoretical Analysis

MedKoo Cat#: 112052

Name: Pulmatin

CAS#: 13241-28-6

Chemical Formula: C21H20O9

Exact Mass: 416.1107

Molecular Weight: 416.38

Elemental Analysis: C, 60.58; H, 4.84; O, 34.58

Price and Availability

Size Price Availability Quantity
1mg USD 280.00 2 Weeks
5mg USD 780.00 2 Weeks
10mg USD 1,320.00 2 Weeks
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Related CAS #
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Synonym
Pulmatin; Chrysophanol 8-O-glucoside; Chrysophanol 8-O-β-D-glucopyranoside; Chrysophanol 8Oglucoside; Chrysophanol 8OβDglucopyranoside; Chrysophanol 8 O glucoside; Chrysophanol 8 O β D glucopyranoside
IUPAC/Chemical Name
1-hydroxy-3-methyl-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)anthracene-9,10-dione
InChi Key
WMMOMSNMMDMSRB-JNHRPPPUSA-N
InChi Code
InChI=1S/C21H20O9/c1-8-5-10-14(11(23)6-8)18(26)15-9(16(10)24)3-2-4-12(15)29-21-20(28)19(27)17(25)13(7-22)30-21/h2-6,13,17,19-23,25,27-28H,7H2,1H3/t13-,17-,19+,20-,21-/m1/s1
SMILES Code
O=C(C1=CC=CC(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=C13)C4=CC(C)=CC(O)=C4C3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 416.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vaziri-Amjad S, Rahgosha R, Taherkhani A. Potential JAK2 Inhibitors from Selected Natural Compounds: A Promising Approach for Complementary Therapy in Cancer Patients. Evid Based Complement Alternat Med. 2024 Apr 26;2024:1114928. doi: 10.1155/2024/1114928. PMID: 38706884; PMCID: PMC11068457. 2: Jamshidi S, Rostami A, Shojaei S, Taherkhani A, Taherkhani H. Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study. Biosystems. 2024 Jan;235:105103. doi: 10.1016/j.biosystems.2023.105103. Epub 2023 Dec 18. PMID: 38123060. 3: Trinh PTN, Giang BL, Tuan NT, Hang HTT, Thuy NTL, Tuan NN, Dung LT. Alfa glucosidase inhibitory, anti inflammatory activities and a new furanocoumarin derivative of Ruellia tuberosa. Nat Prod Res. 2021 Nov;35(22):4248-4255. doi: 10.1080/14786419.2019.1696790. Epub 2019 Nov 29. PMID: 31782667. 4: Diaz F, Chai HB, Mi Q, Su BN, Vigo JS, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru. J Nat Prod. 2004 Mar;67(3):352-6. doi: 10.1021/np030479j. PMID: 15043409.