MedKoo Cat#: 408139 | Name: VT101 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.

Chemical Structure

VT101 free base
VT101 free base
CAS#65194-64-1 (free base)

Theoretical Analysis

MedKoo Cat#: 408139

Name: VT101 free base

CAS#: 65194-64-1 (free base)

Chemical Formula: C14H20N2O4S

Exact Mass: 312.1144

Molecular Weight: 312.38

Elemental Analysis: C, 53.83; H, 6.45; N, 8.97; O, 20.49; S, 10.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
65194-64-1 (free base) 65194-65-2 (HCl)
Synonym
VT101; VT-101; VT 101;
IUPAC/Chemical Name
methyl 2-(cyclohexylamino)-5-sulfamoylbenzoate
InChi Key
CCFPLJFSHRAQPV-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H20N2O4S/c1-20-14(17)12-9-11(21(15,18)19)7-8-13(12)16-10-5-3-2-4-6-10/h7-10,16H,2-6H2,1H3,(H2,15,18,19)
SMILES Code
O=C(C1=C(C=CC(S(=O)(N)=O)=C1)NC2CCCCC2)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 312.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Apr 13:molcanther.0717.2020. doi: 10.1158/1535-7163.MCT-20-0717. Epub ahead of print. PMID: 33850002.