Doconazole | CAS# 59831-63-9 | Antifungal

MedKoo Cat#: 413878 | Name: Doconazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Doconazole is an Antifungal. It is the first of the dioxolane series, which was later to produce ketoconazole, to appear as a potential drug. Antifungal activity of doconazole was compared with miconazole and amphotericin B activity against a number of pathogenic filamentous fungi.

Chemical Structure

Doconazole

CAS#59831-63-9

Theoretical Analysis

MedKoo Cat#: 413878

Name: Doconazole

CAS#: 59831-63-9

Chemical Formula: C26H22Cl2N2O3

Exact Mass: 480.1007

Molecular Weight: 481.37

Elemental Analysis: C, 64.87; H, 4.61; Cl, 14.73; N, 5.82; O, 9.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Doconazole; R34000 R-34000; R 34000

IUPAC/Chemical Name

1H-Imidazole, 1-((4-(((1,1'-biphenyl)-4-yloxy)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl)methyl)-, cis-

InChi Key

GNZHVEIGGFMLSP-ZEQKJWHPSA-N

InChi Code

InChI=1S/C26H22Cl2N2O3/c27-21-8-11-24(25(28)14-21)26(17-30-13-12-29-18-30)32-16-23(33-26)15-31-22-9-6-20(7-10-22)19-4-2-1-3-5-19/h1-14,18,23H,15-17H2/t23-,26-/m1/s1

SMILES Code

ClC1=CC=C([C@]2(CN3C=CN=C3)OC[C@@H](COC4=CC=C(C5=CC=CC=C5)C=C4)O2)C(Cl)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 481.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Levine HB. R34000, a dioxolane imidazole in the therapy for experimental coccidioidomycosis. Comparison with miconazole and econazole. Chest. 1976 Dec;70(6):755-9. doi: 10.1378/chest.70.6.755. PMID: 1001052.