IUPAC/Chemical Name
4-Pyridinecarboxylic acid, (3-(2-furanyl)-1-methyl-2-propenylidene)hydrazide
InChi Key
QUVHKWHEWFRMPK-MROGMESDSA-N
InChi Code
InChI=1S/C14H13N3O2/c1-11(4-5-13-3-2-10-19-13)16-17-14(18)12-6-8-15-9-7-12/h2-10H,1H3,(H,17,18)/b5-4+,16-11+
SMILES Code
O=C(C1=CC=NC=C1)N/N=C(C)/C=C/C2=CC=CO2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
255.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: KOMARITSIA ID. [A compleximetric method for the quantitative determination of larusan in powder and tablets]. Farm Zh. 1961;16(6):31-4. Ukrainian. PMID: 14458094.
3: SUPRUN PP. [Iodochlorometric method for the quantitative determination of formaldehyde and acetone and a new qualitative reaction for larusan]. Farm Zh. 1962;17(6):37-40. Ukrainian. PMID: 13979319.
4: CHERTKOVA EI. Ispytanie larusana v eksperimente pri tuberkuleze [Studies on larusan in experimental tuberculosis]. Probl Tuberk. 1957;35(3):92-7. Russian. PMID: 13484938.
5: Fartushnyĭ AF. Opredelenie larusana v biologicheskom materiale [Determination of larusan in biological material]. Sud Med Ekspert. 1977 Apr-Jun;20(2):46-8. Russian. PMID: 16366.
6: Laĭpanov AKh, Lobanov VI. Interferometrychne vyznachennia larusanu. tibonu ĭ etoksydu v preparatakh i likars'kykh formakh [Interferometric determination of larusan, tibon and ethoxyd in preparations and drug forms]. Farm Zh. 1973 Nov- Dec;28(6):43-6. Ukrainian. PMID: 4134665.
7: IVASHCHENKO EA. Blizhaishie rezul'taty lecheniia larusanom bol'nykh tuberkulezom verkhnikh dykhatel'nykh putei i polosti rta [Immediate results of larusan therapy in tuberculosis of the upper respiratory tract and oral cavity]. Probl Tuberk. 1956;34(Suppl 6):18-9. Russian. PMID: 13420107.
8: Smirnov GA, Efremova ZR, Galkeeva TN. O sravnitel'noĭ tsennosti tubazida, larusana i preparata INKh-17 [Comparative value of tubazid, larusan and preparation INKh-17]. Probl Tuberk. 1970;48(4):29-36. Russian. PMID: 5471127.
9: Vergeĭchik EN, Bernshteĭn VN, Zvenigorodskiĭ BIa. Fotometricheskoe opredelenie larusana v tabletkakh [Photometric determination of larusan in tablets]. Farmatsiia. 1967 Mar-Apr;16(2):41-5. Russian. PMID: 5611768.
10: BARYSHNIKOV AS, EGOROVA KT, NEVEROV GA, PRONINA EA, UDILOVA NN. Vliianie larusana na kharakter tuberkulinovykh reaktsii pri eksperimental'nom tuberkuleze [Effect of larusan on tuberculin reaction in experimental tuberculosis]. Probl Tuberk. 1956 Mar-Apr;34(2):61-4. Russian. PMID: 13335992.
11: BUTKIN NG, SHELKOVKINA AV, NAZAROVA IB. Lechenie larusanom bol'nykh legochnym tuberskulezom; predvaritel'noe soobshchenie [Larusan therapy of pulmonary tuberculosis; preliminary communication]. Probl Tuberk. 1956 Mar- Apr;34(2):36-9. Russian. PMID: 13335986.
12: Storozhuk PG, Skliar VA, Korochanskaia SP, Gontmakher IuV. Utilizatsiia gliukozy i aktivnost' gliukozo-6-fosfatdegidrogenazy, izotsitratdegidrogenazy i malatdegidrogenazy éritrotsitov krys pri deĭstvii tuberkulostaticheskimi preparatami [Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents]. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5. Russian. PMID: 3776114.
13: Shapiro AA, Meksin VA, Abilev SK, Akin'shina LP, Fonshteĭn LM. Izuchenie mutagennoĭ aktivnosti protivotuberkuleznykh preparatov: gidrazida izonikotinovoĭ kisloty i ego proizvodnykh [Mutagenic activity of antitubercular preparations: isonicotinic acid hydrazide and its derivatives]. Tsitol Genet. 1978 Jul- Aug;12(4):343-8. Russian. PMID: 360538.
