Govitecan (also known as SN-38 or in its prodrug conjugated form, sacituzumab govitecan) is a potent topoisomerase I inhibitor and the active metabolite of irinotecan. In preclinical studies, SN-38 exhibits nanomolar cytotoxic activity against a wide range of tumor cell lines, with IC₅₀ values typically ranging from 0.1 to 10 nM. Sacituzumab govitecan, an antibody-drug conjugate (ADC) linking SN-38 to an anti-Trop-2 monoclonal antibody via a hydrolyzable linker, delivers targeted cytotoxicity to Trop-2–expressing tumors.
MedKoo Cat#: 598192
Name: Govitecan
CAS#: 1918106-06-5
Chemical Formula: C73H99N11O22
Exact Mass: 1481.6966
Molecular Weight: 1482.65
Elemental Analysis: C, 59.14; H, 6.73; N, 10.39; O, 23.74
The following data is based on the product molecular weight 1,482.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
