BI01383298 | CAS# 2227549-00-8 | SLC13A5 Inhibitor

MedKoo Cat#: 564050 | Name: BI01383298

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI01383298 is a potent inhibitor of SLC13A5, being selective over other family members and other transporters.

Chemical Structure

BI01383298

CAS#2227549-00-8

Theoretical Analysis

MedKoo Cat#: 564050

Name: BI01383298

CAS#: 2227549-00-8

Chemical Formula: C19H19Cl2FN2O3S

Exact Mass: 444.0477

Molecular Weight: 445.33

Elemental Analysis: C, 51.24; H, 4.30; Cl, 15.92; F, 4.27; N, 6.29; O, 10.78; S, 7.20

Price and Availability

Size	Price	Availability
10mg	USD 120.00	Ready to ship
25mg	USD 250.00	Ready to ship
50mg	USD 450.00	Ready to ship
100mg	USD 750.00	Ready to ship
200mg	USD 1,250.00	Ready to ship
500mg	USD 2,450.00	Ready to ship
1g	USD 3,450.00	Ready to ship
2g	USD 5,950.00	Ready to ship

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

BI01383298; BI-01383298; BI 01383298;

IUPAC/Chemical Name

1-((3,5-Dichlorophenyl)sulfonyl)-N-(4-fluorobenzyl)piperidine-4-carboxamide

InChi Key

VUOYAALVGSMUHC-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19Cl2FN2O3S/c20-15-9-16(21)11-18(10-15)28(26,27)24-7-5-14(6-8-24)19(25)23-12-13-1-3-17(22)4-2-13/h1-4,9-11,14H,5-8,12H2,(H,23,25)

SMILES Code

O=C(C1CCN(S(=O)(C2=CC(Cl)=CC(Cl)=C2)=O)CC1)NCC3=CC=C(F)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A9T12K10

View CoA: current batch, Lot#A9T12K23

QC Data

View QC data: current batch, Lot#A9T12K10

View QC data: current batch, Lot#A9T12K23

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

BI 01383298 is an inhibitor of the sodium-citrate co-transporter (SLC13A5) that is highly expressed in the liver.

In vitro activity:

This experiment was repeated with Li+ present during the uptake assay. Again, the inhibition was almost complete and the concentration needed for 50% inhibition was 2-fold lower in the presence of Li+ than in its absence (49 ± 3 nM in the presence of Li+; 118 ± 22 nM in the absence of Li+). These values were significantly lower than the corresponding values when the cells were not preincubated with the inhibitor (∼0.5 µM in the presence of Li+; 3 µM in the absence of Li+) (Figure 1A). These data suggest that the inhibitory potency for BI01383298 increases by ∼10-fold, both in the absence or presence of Li+, when the cells were subjected to preincubation with the inhibitor. Reference: Biochem J. 2020 Nov 13; 477(21): 4149–4165. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657661/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	29.9	67.12

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 445.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Higuchi K, Kopel JJ, Sivaprakasam S, Jaramillo-Martinez V, Sutton RB, Urbatsch IL, Ganapathy V. Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY). Biochem J. 2020 Nov 13;477(21):4149-4165. doi: 10.1042/BCJ20200592. PMID: 33079129; PMCID: PMC7657661.

In vitro protocol:

In vivo protocol:

TBD

1: Higuchi K, Kopel JJ, Sivaprakasam S, Jaramillo-Martinez V, Sutton RB, Urbatsch IL, Ganapathy V. Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY). Biochem J. 2020 Nov 13;477(21):4149-4165. doi: 10.1042/BCJ20200592. PMID: 33079129; PMCID: PMC7657661. 2: Surrer DB, Fromm MF, Maas R, König J. L-Arginine and Cardioactive Arginine Derivatives as Substrates and Inhibitors of Human and Mouse NaCT/Nact. Metabolites. 2022 Mar 22;12(4):273. doi: 10.3390/metabo12040273. PMID: 35448460; PMCID: PMC9026504.