Synonym
DJ 7141; DJ-7141; DJ7141
IUPAC/Chemical Name
1H-Imidazo(1,2-a)imidazole, 2-(2-chloro-6-fluorophenyl)-2,3,5,6-tetrahydro-, monohydrochloride
InChi Key
GIKGLDSFRANZKP-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11ClFN3.ClH/c12-7-2-1-3-8(13)10(7)9-6-16-5-4-14-11(16)15-9;/h1-3,9H,4-6H2,(H,14,15);1H
SMILES Code
FC1=C(C2NC3=NCCN3C2)C(Cl)=CC=C1.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
276.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Muramatsu I, Oshita M, Hashimoto S, Kigoshi S. DJ-7141, a new alpha-2 agonist with only a mild hypotensive action. Jpn J Pharmacol. 1986 May;41(1):61-8. doi: 10.1254/jjp.41.61. PMID: 2874252.
2: Furukawa Y, Saegusa K, Ogiwara Y, Takeda M, Chiba S. Effects of DJ-7141, a new alpha-2 agonist, 2-(2-chloro-6-fluorophenyl)-2,3,5,6-tetra- hydro-1H-imidazo[1,2-a] imidazole hydrochloride, on the isolated atrium, cross- perfused with blood from a support dog. Jpn Heart J. 1987 Nov;28(6):913-22. doi: 10.1536/ihj.28.913. PMID: 2895194.
3: Yokotani K, Osumi Y. Effects of DJ-7141, a new peripherally acting alpha-2 adrenoceptor agonist, on blood pressure and gastric acid output in rats: evidence for the heterogeneity of alpha-2 adrenoceptors in different organs. Jpn J Pharmacol. 1987 Apr;43(4):415-22. doi: 10.1254/jjp.43.415. PMID: 2886689.
4: Oka M, Misbahuddin M, Ishimura Y, Morita K. Effects of DJ-7141, a new alpha 2-adrenoceptor agonist, on catecholamine secretion from isolated bovine adrenal medullary cells. Biochem Pharmacol. 1987 Mar 1;36(5):609-12. doi: 10.1016/0006-2952(87)90709-x. PMID: 2881545.
5: Chiba S, Tsukada M. Pharmacological analysis of vasodilator responses to alpha 2-adrenoceptor agonists in isolated rat common carotid arteries. Jpn J Pharmacol. 1990 Jun;53(2):135-43. doi: 10.1254/jjp.53.135. PMID: 1974660.
