Igmesine, also known as JO-1784 and CI1019, is a selective and potent σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). It inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Igmesine Hydrochloride is a weak inhibitor of brain 5-HT uptake in vitro. It exhibits neuroprotective and antidepressant effects.
MedKoo Cat#: 576599
Name: Igmesine free base
CAS#: 140850-73-3 (free base)
Chemical Formula: C23H29N
Exact Mass: 319.2300
Molecular Weight: 319.49
Elemental Analysis: C, 86.47; H, 9.15; N, 4.38
The following data is based on the product molecular weight 319.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
