Synonym
Dithiazanine; Dithiazaninum; 3,3'-Diethylthiadicarbocyanine; Dithiazanine cation
IUPAC/Chemical Name
Benzothiazolium, 3-ethyl-2-(5-(3-ethyl-2(3H)-benzothiazolylidene)-1,3-pentadienyl)-
InChi Key
FYXWDSGGZAMYFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23N2S2/c1-3-24-18-12-8-10-14-20(18)26-22(24)16-6-5-7-17-23-25(4-2)19-13-9-11-15-21(19)27-23/h5-17H,3-4H2,1-2H3/q+1
SMILES Code
CCN1/C(SC2=CC=CC=C12)=C\C=C\C=C\C3=[N+](CC)C4=CC=CC=C4S3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
391.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: SWARTZWELDER JC, FRYE WW, MUHLEISEN JP, MILLER JH, LAMPERT R, PENA CHAVARRIA A, ABADIE SH, ANTHONY SO, SAPPENFIELD RW. Dithiazanine, an effective broad- spectrum anthelmintic; results of therapy of trichuriasis, strongyloidiasis, enterobiasis, ascariasis, and hookworm infection. J Am Med Assoc. 1957 Dec 21;165(16):2063-7. doi: 10.1001/jama.1957.02980340029008. PMID: 13480859.
2: VINKE B, van der SAR. Dithiazanine, a new anthelminthic. Trop Geogr Med. 1959 Dec;11:335-8. PMID: 13842392.
3: Dillon R. Feline dirofilariasis. Vet Clin North Am Small Anim Pract. 1984 Nov;14(6):1185-99. doi: 10.1016/s0195-5616(84)50153-3. PMID: 6393552.
4: PAINE DH, LOWER ES, COOPER TV. Treatment of trichuriasis with dithiazanine; a preliminary report. Br Med J. 1959 Jan 10;1(5114):93-5. doi: 10.1136/bmj.1.5114.93. PMID: 13608089; PMCID: PMC1992214.
5: SWARTZWELDER JC, LAMPERT R, MILLER JH, SAPPENFIELD RW, FRYE WW, ABADIE SH, COCO LJ. Therapy of trichuriasis and ascariasis with dithiazanine. Am J Trop Med Hyg. 1958 May;7(3):329-33. doi: 10.4269/ajtmh.1958.7.329. PMID: 13533741.
6: ABADIE SH, SAMUELS M. A FATALITY ASSOCIATED WITH DITHIAZANINE IODIDE THERAPY. JAMA. 1965 Apr 26;192:326-7. doi: 10.1001/jama.1965.03080170054020. PMID: 14271987.
7: GUERRERO L, HOLGUIN J, BOTERO D. The use of dithiazanine as a mass treatment for intestinal helminthiasis. Am J Trop Med Hyg. 1960 Jan;9:37-8. doi: 10.4269/ajtmh.1960.9.37. PMID: 13830051.
8: DING LK, SUTLIVE J. The use of dithiazanine iodide in the treatment of multiple helminthiasis in Sarawak, Borneo. Am J Trop Med Hyg. 1960 Sep;9:503-5. doi: 10.4269/ajtmh.1960.9.503. PMID: 13722979.
9: AGUILAR FJ. The polyanthelmintic action of dithiazanine iodide; verification of its effectiveness in the most common helminthiases in Guatemala. Am J Trop Med Hyg. 1959 May;8(3):305-6. doi: 10.4269/ajtmh.1959.8.305. PMID: 13661527.
10: HAMMOND JB, McCOWEN MC. The treatment of enterobiasis with new formulations of dithiazanine iodide. Am J Trop Med Hyg. 1960 Sep;9:500-2. doi: 10.4269/ajtmh.1960.9.500. PMID: 13711084.
