Boxidine | CAS# 10355-14-3 | inhibits sterol absorption

MedKoo Cat#: 413029 | Name: Boxidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Boxidine inhibits the transformation of 7-dehydrocholesterol to cholesterol & also inhibits sterol absorption.

Chemical Structure

Boxidine

CAS#10355-14-3

Theoretical Analysis

MedKoo Cat#: 413029

Name: Boxidine

CAS#: 10355-14-3

Chemical Formula: C19H20F3NO

Exact Mass: 335.1497

Molecular Weight: 335.37

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 68.05; H, 6.01; F, 16.99; N, 4.18; O, 4.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Boxidine; CL65205; CL-65205; CL 65205

IUPAC/Chemical Name

Pyrrolidine, 1-(2-((4'-(trifluoromethyl)(1,1'-biphenyl)-4-yl)oxy)ethyl)-

InChi Key

FOCUKKUAGZPPCU-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H20F3NO/c20-19(21,22)17-7-3-15(4-8-17)16-5-9-18(10-6-16)24-14-13-23-11-1-2-12-23/h3-10H,1-2,11-14H2

SMILES Code

FC(C1=CC=C(C2=CC=C(OCCN3CCCC3)C=C2)C=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 335.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Leignadier J, Dalenc F, Poirot M, Silvente-Poirot S. Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM- mediated autophagy, cell differentiation and death. Biochem Pharmacol. 2017 Nov 15;144:18-28. doi: 10.1016/j.bcp.2017.06.120. Epub 2017 Jun 19. PMID: 28642035. 2: Gailani S, Holland JF, Glick A. Effects of boxidine on human serum sterols and neoplasms. Clin Pharmacol Ther. 1972 Jan-Feb;13(1):91-6. doi: 10.1002/cpt197213191. PMID: 5008195.