dTMP sodium salt | CAS#33430-62-5 | Deoxyribonucleotide

MedKoo Cat#: 464508 | Name: dTMP sodium salt

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

5'-Thymidylic acid (dTMP) is a deoxyribonucleotide. It is formed via methylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis. Oral administration of dTMP in combination with dCMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.

Chemical Structure

dTMP sodium salt

CAS#33430-62-5

Theoretical Analysis

MedKoo Cat#: 464508

Name: dTMP sodium salt

CAS#: 33430-62-5

Chemical Formula: C10H13N2Na2O8P

Exact Mass: 366.0205

Molecular Weight: 366.17

Elemental Analysis: C, 32.80; H, 3.58; N, 7.65; Na, 12.56; O, 34.95; P, 8.46

Price and Availability

Size	Price	Availability
100mg	USD 250.00	2 Weeks
250mg	USD 450.00	2 Weeks
1g	USD 850.00	2 Weeks

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Related CAS #

No Data

Synonym

dTMP; TMP; 5'-Thymidylic Acid (sodium salt); Deoxythymidine-5’-monophosphate; Thymidine monophosphate; Thymidine-5’-monophosphate;

IUPAC/Chemical Name

sodium ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl phosphate

InChi Key

AGSQMPPRYZYDFV-ZJWYQBPBSA-L

InChi Code

InChI=1S/C10H15N2O8P.2Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18);;/q;2*+1/p-2/t6-,7+,8+;;/m0../s1

SMILES Code

O=C(C(C)=CN1[C@]2(C[C@@H]([C@H](O2)COP([O-])([O-])=O)O)[H])NC1=O.[Na+].[Na+]

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	Water	125.0	341.37

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 366.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

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