UR-7247 | CAS#177847-28-8 | Angiotensin Type 1 Receptor Antagonist

MedKoo Cat#: 528422 | Name: UR-7247

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UR-7247 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. UR-7247 has a very long plasma elimination half-life, which may be due to a high but also tight binding to protein binding sites.

Chemical Structure

UR-7247

CAS#177847-28-8

Theoretical Analysis

MedKoo Cat#: 528422

Name: UR-7247

CAS#: 177847-28-8

Chemical Formula: C24H26N6O2

Exact Mass: 430.2117

Molecular Weight: 430.51

Elemental Analysis: C, 66.96; H, 6.09; N, 19.52; O, 7.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

UR-7247, UR 7247, UR7247

IUPAC/Chemical Name

5-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-3-isopropyl-1-propyl-1H-pyrazole-4-carboxylic acid

InChi Key

FOVKKLYIXHRZPA-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H26N6O2/c1-4-13-30-20(21(24(31)32)22(27-30)15(2)3)14-16-9-11-17(12-10-16)18-7-5-6-8-19(18)23-25-28-29-26-23/h5-12,15H,4,13-14H2,1-3H3,(H,31,32)(H,25,26,28,29)

SMILES Code

O=C(C1=C(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)N(CCC)N=C1C(C)C)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 430.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Maillard MP, Rossat J, Nussberger J, Ramis J, Pontes C, Burnier M, Brunner HR. Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6. J Cardiovasc Pharmacol. 2000 Mar;35(3):383-9. PubMed PMID: 10710122.