UR-NR266 | CAS#unknown | Fluorescent H3R ligand

MedKoo Cat#: 465222 | Name: UR-NR266

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UR-NR266 is a novel fluorescent H3R ligand with sub-nanomolar potency. UR-NR266 enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor.

Chemical Structure

UR-NR266

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465222

Name: UR-NR266

CAS#: unknown

Chemical Formula: C54H70N6O9

Exact Mass: 946.5204

Molecular Weight: 947.19

Elemental Analysis: C, 68.48; H, 7.45; N, 8.87; O, 15.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

UR-NR266; URNR266; UR NR266;

IUPAC/Chemical Name

2-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)-5-((1-oxo-1-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-5,8,11-trioxa-2-azatridecan-13-yl)carbamoyl)benzoate

InChi Key

HCGJLZJKRXHJPL-UHFFFAOYSA-N

InChi Code

InChI=1S/C54H70N6O9/c1-57(2)42-12-17-46-49(36-42)69-50-37-43(58(3)4)13-18-47(50)51(46)45-16-11-41(35-48(45)54(63)64)53(62)56-22-30-66-32-34-67-33-31-65-29-21-55-52(61)40-19-26-60(27-20-40)38-39-9-14-44(15-10-39)68-28-8-25-59-23-6-5-7-24-59/h9-18,35-37,40H,5-8,19-34,38H2,1-4H3,(H2-,55,56,61,62,63,64)

SMILES Code

O=C([O-])C1=CC(C(NCCOCCOCCOCCNC(C2CCN(CC3=CC=C(OCCCN4CCCCC4)C=C3)CC2)=O)=O)=CC=C1C5=C6C=C/C(C=C6OC7=C5C=CC(N(C)C)=C7)=[N+](C)/C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 947.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rosier N, Grätz L, Schihada H, Möller J, Işbilir A, Humphrys LJ, Nagl M, Seibel U, Lohse MJ, Pockes S. A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor. J Med Chem. 2021 Jul 26. doi: 10.1021/acs.jmedchem.1c01089. Epub ahead of print. PMID: 34309390.