ICI-206970 | CAS# 119646-52-5 | Biochemical

MedKoo Cat#: 576528 | Name: ICI-206970

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-206970 is a eukalemic diuretic with effects on sodium and water excretion similar to hydrochlorothiazide.

Chemical Structure

ICI-206970

CAS#119646-52-5

Theoretical Analysis

MedKoo Cat#: 576528

Name: ICI-206970

CAS#: 119646-52-5

Chemical Formula: C21H31BrClN7O2

Exact Mass: 527.1411

Molecular Weight: 528.88

Elemental Analysis: C, 47.69; H, 5.91; Br, 15.11; Cl, 6.70; N, 18.54; O, 6.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ICI206970; ICI 206970; ICI-206970

IUPAC/Chemical Name

Pyrazinecarboxamide, 3,5-diamino-N-(2-((2-(((3-bromo-5-(1,1-dimethylethyl)-2-hydroxyphenyl)methyl)amino)ethyl)methylamino)ethyl)-6-chloro-

InChi Key

BOOGSGUHOOWQBH-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H31BrClN7O2/c1-21(2,3)13-9-12(16(31)14(22)10-13)11-26-5-7-30(4)8-6-27-20(32)15-18(24)29-19(25)17(23)28-15/h9-10,26,31H,5-8,11H2,1-4H3,(H,27,32)(H4,24,25,29)

SMILES Code

CN(CCNCc1cc(cc(Br)c1O)C(C)(C)C)CCNC(=O)c2nc(Cl)c(N)nc2N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 528.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Johnston PA, Kau ST. A micropuncture study on the renal site of action of ICI 206,970, a unique eukalemic diuretic. J Pharmacol Exp Ther. 1993 Feb;264(2):604-8. PMID: 8437111. 2. Kau S, Johnston P, Li J, Zuzack J, Leszczynska K, Yochim C, Schwartz J, Giles R. ICI 206,970: a novel eukalemic diuretic with calcium channel blocking activity. Methods Find Exp Clin Pharmacol. 1993 Jul-Aug;15(6):357-69. PMID: 8231455. 3. Howe BB, Keith RA, Do ML, Halterman TJ, Donahue JY, Schwartz JA, Kau ST. ICI 206,970: a novel calcium channel blocker with eukalemic diuretic activity. Pharmacology. 1993 Dec;47(6):369-77. doi: 10.1159/000139120. PMID: 8278459.