KUNG38 | CAS#1887033-00-2 | Grp94 Inhibitor

MedKoo Cat#: 571302 | Name: KUNG38

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KUNG38 is a purine-based inhibitor of Grp94. Specifically, it is a Grp94-selective inhibitor isolated through probing of the exclusive binding region of S1 subpocket in Grp94.

Chemical Structure

KUNG38

CAS#1887033-00-2

Theoretical Analysis

MedKoo Cat#: 571302

Name: KUNG38

CAS#: 1887033-00-2

Chemical Formula: C18H16Cl2N2O5

Exact Mass: 410.0436

Molecular Weight: 411.24

Elemental Analysis: C, 52.57; H, 3.92; Cl, 17.24; N, 6.81; O, 19.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KUNG38; KUNG-38; KUNG 38

IUPAC/Chemical Name

methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate

InChi Key

HIYQDMHJUHUDDN-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16Cl2N2O5/c1-26-18(25)16-11(17(20)13(24)8-12(16)23)3-5-15-21-6-7-22(15)9-10-2-4-14(19)27-10/h2,4,6-8,23-24H,3,5,9H2,1H3

SMILES Code

ClC1=CC=C(CN2C=CN=C2CCC3=C(C(OC)=O)C(O)=CC(O)=C3Cl)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Hsp90 proteins are responsible for the maturation and activation of more than 300 polypeptides into proteins; they also remature denatured proteins. These products are often involved in signaling pathways implicated in cancer transformation, and thus Hsp90 inhibition has emerged as a combinatorial attack against cancer via a single molecular target. More specifically, in the ER, the Hsp90 form present is Grp94. It matures and transports proteins for signaling and cellular adhesion, which eventually play a role in integrin maturation and cell polarity. This target could play an important role in hepatocellular carcinoma, multiple myeloma, rheumatoid arthritis, and glaucoma. Grp94 is essential during embryonic development and thus represents a nontoxic target that can be inhibited to treat these diseases.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Khandelwal A, Crowley VM, Blagg BSJ. Resorcinol-Based Grp94-Selective Inhibitors. ACS Medicinal Chemistry Letters. 2017 September 1. doi: 10.1021/acsmedchemlett.7b00193