MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 413819 | Name: Diproteverine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diproteverine HCl is a calcium channel blocker.

Chemical Structure

Diproteverine HCl
Diproteverine HCl
CAS#69373-88-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 413819

Name: Diproteverine HCl

CAS#: 69373-88-2 (HCl)

Chemical Formula: C26H36ClNO4

Exact Mass: 461.2333

Molecular Weight: 462.03

Elemental Analysis: C, 67.59; H, 7.85; Cl, 7.67; N, 3.03; O, 13.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
69373-88-2 (HCl) 69373-95-1 (free base)
Synonym
Diproteverine HCl; Diproteverine hydrochloride
IUPAC/Chemical Name
1-(3',4'-Diethoxybenzyl)-6,7-diisoprooxy-3,4-dihydroisoquinoline hydrochloride
InChi Key
AWQPJKUSDUHYIX-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H35NO4.ClH/c1-7-28-23-10-9-19(14-24(23)29-8-2)13-22-21-16-26(31-18(5)6)25(30-17(3)4)15-20(21)11-12-27-22;/h9-10,14-18H,7-8,11-13H2,1-6H3;1H
SMILES Code
CC(OC1=CC2=C(C=C1OC(C)C)CCN=C2CC3=CC=C(OCC)C(OCC)=C3)C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 462.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kantelip JP, Talmant JM, Duchene-Marullaz P. Effects of diproteverine, a new calcium antagonist on sinoatrial node and atrioventricular conduction in conscious unsedated dogs. J Cardiovasc Pharmacol. 1988 Oct;12(4):432-7. PubMed PMID: 2465443. 2: Lacroix P, Linee P, Forest MC. Diproteverine (BRL 40015): a new type of calcium antagonist with potential antianginal properties. Eur J Pharmacol. 1991 Jan 17;192(3):317-27. PubMed PMID: 2055233. 3: Berson G. Ca2+ measurement with a Ca electrode: artifacts due to some cardiotropic drugs. Anal Biochem. 1988 Sep;173(2):246-50. PubMed PMID: 3189807. 4: Ridings JE, Palmer AK, Davidson EJ, Baldwin JA. Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine. Reprod Toxicol. 1996 Jan-Feb;10(1):43-9. PubMed PMID: 8998385. 5: Delaunay T, Duval J. [Comparative effect of a new calcium antagonist, BRL 40015, and verapamil on LH secretion from cultured pituitary cells]. C R Acad Sci III. 1985;300(17):627-32. French. PubMed PMID: 3939290.