Diproteverine | CAS#69373-95-1 (free base) | calcium antagonist

MedKoo Cat#: 584265 | Name: Diproteverine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diproteverine is a calcium antagonist with antianginal properties.

Chemical Structure

Diproteverine

CAS#69373-95-1 (free base)

Theoretical Analysis

MedKoo Cat#: 584265

Name: Diproteverine

CAS#: 69373-95-1 (free base)

Chemical Formula: C26H35NO4

Exact Mass: 425.2566

Molecular Weight: 425.57

Elemental Analysis: C, 73.38; H, 8.29; N, 3.29; O, 15.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

69373-88-2 (HCl) 69373-95-1 (free base)

Synonym

Diproteverine

IUPAC/Chemical Name

1-(3,4-Diethoxybenzyl)-3,4-dihydro-6,7-diisopropoxyisoquinoline

InChi Key

APMMVXSVJLZZRR-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H35NO4/c1-7-28-23-10-9-19(14-24(23)29-8-2)13-22-21-16-26(31-18(5)6)25(30-17(3)4)15-20(21)11-12-27-22/h9-10,14-18H,7-8,11-13H2,1-6H3

SMILES Code

CC(OC1=CC2=C(C=C1OC(C)C)CCN=C2CC3=CC=C(OCC)C(OCC)=C3)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 425.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kantelip JP, Talmant JM, Duchene-Marullaz P. Effects of diproteverine, a new calcium antagonist on sinoatrial node and atrioventricular conduction in conscious unsedated dogs. J Cardiovasc Pharmacol. 1988 Oct;12(4):432-7. PubMed PMID: 2465443. 2: Lacroix P, Linee P, Forest MC. Diproteverine (BRL 40015): a new type of calcium antagonist with potential antianginal properties. Eur J Pharmacol. 1991 Jan 17;192(3):317-27. PubMed PMID: 2055233. 3: Berson G. Ca2+ measurement with a Ca electrode: artifacts due to some cardiotropic drugs. Anal Biochem. 1988 Sep;173(2):246-50. PubMed PMID: 3189807. 4: Ridings JE, Palmer AK, Davidson EJ, Baldwin JA. Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine. Reprod Toxicol. 1996 Jan-Feb;10(1):43-9. PubMed PMID: 8998385. 5: Delaunay T, Duval J. [Comparative effect of a new calcium antagonist, BRL 40015, and verapamil on LH secretion from cultured pituitary cells]. C R Acad Sci III. 1985;300(17):627-32. French. PubMed PMID: 3939290.