NAZ2329 | CAS#unknown | PTPase inhibitor

MedKoo Cat#: 464473 | Name: NAZ2329

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NAZ2329 is a novel cell-permeable PTPase inhibitor, targeting PTPRZ and inhibiting stem cell-like properties and tumorigenicity in glioblastoma cells.

Chemical Structure

NAZ2329

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464473

Name: NAZ2329

CAS#: unknown

Chemical Formula: C21H18F3NO4S3

Exact Mass: 501.0350

Molecular Weight: 501.55

Elemental Analysis: C, 50.29; H, 3.62; F, 11.36; N, 2.79; O, 12.76; S, 19.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NAZ2329; NAZ 2329; NAZ-2329;

IUPAC/Chemical Name

3-((2-ethoxy-5-(trifluoromethyl)benzyl)thio)-N-(phenylsulfonyl)thiophene-2-carboxamide

InChi Key

AKXBLDKCMACKRY-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H18F3NO4S3/c1-2-29-17-9-8-15(21(22,23)24)12-14(17)13-31-18-10-11-30-19(18)20(26)25-32(27,28)16-6-4-3-5-7-16/h3-12H,2,13H2,1H3,(H,25,26)

SMILES Code

O=C(C1=C(SCC2=CC(C(F)(F)F)=CC=C2OCC)C=CS1)NS(=O)(C3=CC=CC=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 501.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fujikawa A, Sugawara H, Tanga N, Ishii K, Kuboyama K, Uchiyama S, Suzuki R, Noda M. A head-to-toe dimerization has physiological relevance for ligand- induced inactivation of protein tyrosine receptor type Z. J Biol Chem. 2019 Oct 11;294(41):14953-14965. doi: 10.1074/jbc.RA119.007878. Epub 2019 Aug 15. PMID: 31416834; PMCID: PMC6791311. 2: Fujikawa A, Sugawara H, Tanaka T, Matsumoto M, Kuboyama K, Suzuki R, Tanga N, Ogata A, Masumura M, Noda M. Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells. Sci Rep. 2017 Jul 17;7(1):5609. doi: 10.1038/s41598-017-05931-8. PMID: 28717188; PMCID: PMC5514153.