ROS-234 dioxalate | CAS# 1781941-93-2 | H3 antagonist

MedKoo Cat#: 574389 | Name: ROS-234 dioxalate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ROS-234 dioxalate is an H3 antagonist with limited blood brain barrier permeability.

Chemical Structure

ROS-234 dioxalate

CAS#1781941-93-2

Theoretical Analysis

MedKoo Cat#: 574389

Name: ROS-234 dioxalate

CAS#: 1781941-93-2

Chemical Formula: C17H19N5O8

Exact Mass:

Molecular Weight: 421.37

Elemental Analysis: C, 48.46; H, 4.55; N, 16.62; O, 30.38

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 450.00	2 Weeks
50mg	USD 1,200.00	2 Weeks

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Related CAS #

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Synonym

ROS-234 dioxalate, ROS234 dioxalate, ROS 234 dioxalate

IUPAC/Chemical Name

N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate

InChi Key

JKTBCMILCFDKEJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H15N5.2C2H2O4/c1-2-6-12-11(5-1)17-13(18-12)15-7-3-4-10-8-14-9-16-10;2*3-1(4)2(5)6/h1-2,5-6,8-9H,3-4,7H2,(H,14,16)(H2,15,17,18);2*(H,3,4)(H,5,6)

SMILES Code

O=C(O)C(O)=O.O=C(O)C(O)=O.C1(NCCCC2=CNC=N2)=NC3=CC=CC=C3N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

ROS 234 dioxalate has a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex.

In vitro activity:

To be determined

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 421.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

To be determined

In vitro protocol:

To be determined

In vivo protocol:

To be determined

1. Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409 2. Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663